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フルテキストURLA050066000101.pdf ( 1.1MB ) 公開日 2019-09-20
タイトルAn invited review following the Soujinkai Young Investigator Award : ryanodine receptor bound calmodulin as a novel therapeutic target of arrhythmias and heart failure
作成者Kato, Takayoshi
Yamamoto, Takeshi
Kobayashi, Shigeki
Yano, Masafumi
作成者ヨミカトウ, タカヨシ
ヤマモト, タケシ
コバヤシ, シゲキ
ヤノ, マサフミ
作成者別表記加藤, 孝佳
山本, 健
小林, 茂樹
矢野, 雅文
作成者所属山口大学大学院医学系研究科(医学)
内容記述(抄録等)Life-threatening situations that can arise in patients with heart failure are widely recognized in clinical cardiology. This occasionally results from ventricular arrhythmias and hence the management of lethal arrhythmias is now one of the most important issues in the treatment of heart failure. In the failing cardiomyocytes, an abnormal regulation of intracellular calcium (Ca^{2+}) handling by a Ca^{2+} release channel of the sarcoplasmic reticulum (SR), so-called ryanodine receptor (RyR2), is known to play an important role in the mechanism underlying cardiac arrhythmias. On the other hand, in catecholaminergic polymorphic ventricular tachycardia (CPVT), mutation- linked defective channel gating of the RyR2 is also known as a major pathogenic mechanism underlying fatal arrhythmias. The knowledge gained from these studies upon the RyR2 and its modulatory proteins, such as calmodulin (CaM), may lead to the development of a new pharmacological or genetic strategy for the treatment of heart failure and cardiac arrhythmias. In this review, we focused on the role of CaM on the regulation of the channel gating of the RyR2 in the pathogenesis of heart failure and fatal arrhythmias, and discuss the possibility of developing a novel therapeutic strategy targeting the RyR2.
本文言語eng
著者キーワードheart failure
lethal arrhythmia
cardiac ryanodine receptor
calmodulin
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
66
1-2
開始ページ1
終了ページ6
発行日2019
著者版/出版社版出版社版
リポジトリIDA050066000101
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050066000101