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フルテキストURLA020036000108.pdf ( 498.4KB ) 公開日 2010-04-19
タイトルColony Formation Assay for In Vitro Chemosensitivity Test of Urologic malignancies
作成者Yamamoto, Norio
Matsuyama, Hideyasu
Sakatoku, Jisaburo
作成者ヨミヤマモト, ノリオ
マツヤマ, ヒデヤス
サカトク, ジサブロウ
作成者所属山口大学医学部
内容記述(抄録等)Over the past years we have attemptted to grow 29 urologic tumors using a soft agar colony formation assay similar to tha originally described by Salmon and colleagues. Formation of colonies in vitro occurred in 45 of 79 primary urologic tumors (57%), including 25 of 41 uroepitherial cancer specimens, 12 of 19 renal cancer specimens and 5 of 12 testicular cancer specimens. Growth sufficient for chemosensitivity testing ranged from 45% of the testicular cancer cultured to 87% of the uroepitherial cancer cultured. Seven of uroepitherial cancer and fur of testicular cancer were demonstrated in the dose of corresponding colony survival curve for Cisplatinum. Nine of renal cancer were demonstrated in the dose corresponding colony survival curve for Interferon. Seventeen patients were used by the identical correlation, twelve drugs in ten cases were evaluated from the objective effects of the treatment. The predictability results were 67-75% true positive and 75-83% true negative, with 75% overall predictability. This assay can therfore be used to study differences of biological characters including drug sensitivity.
本文言語eng
著者キーワードColony formation assay
In vitro chemosensitivity test
Urologic malignancies
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
36
1-2
開始ページ49
終了ページ54
発行日1989-06
著者版/出版社版出版社版
リポジトリIDA020036000108
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020036000108