| フルテキストURL | A050064000301.pdf ( 754.1KB ) 公開日 2018-03-29
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| タイトル | An invited review following the Soujinkai Award : tissue-specific expression of estrogen receptor1 is regulated by DNA methylation in a T-DMR |
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| 作成者 | Maekawa, Ryo
Sugino, Norihiro
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| 作成者ヨミ | マエカワ, リョウ
スギノ, ノリヒロ
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| 作成者別表記 | 前川, 亮
杉野, 法広
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| 作成者所属 | 山口大学医学部附属病院
山口大学大学院医学系研究科（医学）
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| 内容記述（抄録等） | ESR1 expression was tissue-specific, being high in the endometrium and mammary gland and low/nil in the placenta and skin.A long-standing question was how this tissue-specific expression of ESR1 was regulated. In other genes, DNA methylation of a region called the T-DMR (tissue-dependent and differentially methylated region) has been associated with tissue-specific gene expression.We recently found that human ESR1 has a T-DMR and DNA methylation of the T-DMR, but not the promoter region, regulates its tissue-specific expression. Furthermore, we revealed that EGR1 is a possible transcription factor to bind the T-DMR and upregulate ESR1 expression under DNA hypomethylation of the T-DMR.
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| 本文言語 | eng
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| 著者キーワード | estrogen receptor 1 (ESR1)
tissue-specific expression
DNA methylation
tissue-dependent and differentially methylated region
breast cancer
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University School of Medicine
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| NII資料タイプ | 紀要論文 |
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| ISSN | 0513-1812
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| NCID | AA00594272
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 巻 | 64 |
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| 号 | 3-4 |
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| 開始ページ | 13 |
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| 終了ページ | 19 |
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| 発行日 | 2017 |
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A050064000301 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050064000301 |
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