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フルテキストURLA050064000301.pdf ( 754.1KB ) 公開日 2018-03-29
タイトルAn invited review following the Soujinkai Award : tissue-specific expression of estrogen receptor1 is regulated by DNA methylation in a T-DMR
作成者Maekawa, Ryo
Sugino, Norihiro
作成者ヨミマエカワ, リョウ
スギノ, ノリヒロ
作成者別表記前川, 亮
杉野, 法広
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)ESR1 expression was tissue-specific, being high in the endometrium and mammary gland and low/nil in the placenta and skin.A long-standing question was how this tissue-specific expression of ESR1 was regulated. In other genes, DNA methylation of a region called the T-DMR (tissue-dependent and differentially methylated region) has been associated with tissue-specific gene expression.We recently found that human ESR1 has a T-DMR and DNA methylation of the T-DMR, but not the promoter region, regulates its tissue-specific expression. Furthermore, we revealed that EGR1 is a possible transcription factor to bind the T-DMR and upregulate ESR1 expression under DNA hypomethylation of the T-DMR.
本文言語eng
著者キーワードestrogen receptor 1 (ESR1)
tissue-specific expression
DNA methylation
tissue-dependent and differentially methylated region
breast cancer
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
64
3-4
開始ページ13
終了ページ19
発行日2017
著者版/出版社版出版社版
リポジトリIDA050064000301
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050064000301