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タイトルCiclosporin, mizoribineがラット同種移植腎の細胞浸潤に及ぼす影響について
タイトルヨミCiclosporin, mizoribine ガ ラット ドウシュ イショクジン ノ サイボウ シンジュン ニ オヨボス エイキョウ ニ ツイテ
タイトル別表記The effects of ciclosporin and mizoribine on cellular infiltration in rat renal allografts
作成者陶山, 健一
作成者ヨミスヤマ, ケンイチ
作成者別表記Suyama, Kenichi
作成者所属山口大学医学部
内容記述(抄録等)The effects of ciclosporin (CsA) and mizoribine (MZ) on cellular infiltration in rat allografts were discussed. Transplanted rats were diveided into three groups : CsA treated group, MZ treated group and non-treated group (Cont group). CsA in a dose of 10mg/kg/day or MZ in a dose of 5 mg/kg/day was administred orally for 5 days after transplantation in each treatment group. The mean survival day of each group was 23.7±7.8 days in CsA group, 18.5±2.8 days in MZ group and 8±0.8 days in Cont group respecitively. They were sacrificed every few days, and then renal allografts were used for pathological examinations, those were H E stain and immunoperoxidase stain (ABC method), in which menoclonal antibodies ; OX8 and W3/25 were used as primary antibodies. In Cont group, mononuclear cells infilitrated in interstitium shortly after transplantation and the number of OX8^+ was greater than that of W3/25^+ CsA group and MZ group showed the same tendency that mononuclear cells were localized in perivasucular and periglomerular space, and the number of W3/25^+ was greater than that of OX8^+ contrary to Cont group. The actue severe rejecrion observed in Cont group was surppressed by the short course treatment of CsA and MZ. The Phenotype of mononuclear cells infiltarted in allografts of CsA and MZ group was modified by each immunosuppresive drug.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
39
3
開始ページ413
終了ページ420
発行日1990-06
著者版/出版社版その他
リポジトリIDB030039000313
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030039000313