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フルテキストURLA050056000103.pdf ( 921.5KB ) 公開日 2010-04-19
タイトルA case of Castleman's disease of hyaline-vascular type associated with pure red cell aplasia which was successfully treated with cyclosporine
作成者Suzukawa, Munehiro
Kondo, Manabu
Sugiyama, Akiko
Tominaga, Takayuki
Shinohara, Kenji
Kamei, Toshiaki
作成者ヨミスズカワ, ムネヒロ
コンドウ, マナブ
スギヤマ, アキコ
トミナガ, タカユキ
シノハラ, ケンジ
カメイ, トシアキ
内容記述(抄録等)A 70-year-old female complained of palpitation. CBC demonstated anemia and bone marrow aspiration smear demonstrated absence of erythroid hematopoietic cells, and pure red cell aplasia (PRCA) was diagnosed. Computed tomography (CT) demonstrated abdominal tumor. Biopsy of the abdominal tumor showed proliferation of lymph follicles with small and medium-sized lymphocytes, angiofollicular pattern in their center, and hyalinization around the surrounding tissue. Based on these findings, Castleman's disease (CD) of hyaline-vascular (HV) type was diagnosed. Since anemia progressed, a possible relation between the pathogenesis of PRCA and CD was considered. Therefore, prednisolone (PSL) was dministered for two months as well as two courses of COP (cyclophosphamide, oncovin and prednisolone) chemotherapy and 40Gy radiation to the abdominal tumor. After these treatments, the size of abdominal tumor decreased, but PRCA did not improve. Subsequently cyclosporine was administered for five months, and was effective for the improvement of anemia. These results indicated the immunological pathogenesis of PRCA even in Castleman's disease of hyaline-vascular type.
本文言語eng
著者キーワードCastleman's disease
hyaline-vascular type
pure red cell aplasia
cyclosporine
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
56
1-2
開始ページ15
終了ページ19
発行日2009
関連情報URL(IsPartOf)http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
著者版/出版社版出版社版
リポジトリIDA050056000103
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050056000103