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フルテキストURLA050063000302.pdf ( 530.5KB ) 公開日 2017-02-06
タイトルAnalysis of single nucleotide polymorphisms of the aryl hydrocarbon receptor in japanese psoriasis patients
作成者Nakamura, Akiko,
Nakamura, Yoshitaka
Tanaka, Akemi
Muto, Masahiko
作成者ヨミナカムラ, アキコ
ナカムラ, ヨシタカ
タナカ, アケミ
ムトウ, マサヒコ
作成者別表記中村, 有希子
中村, 好貴
田中, 朱美
武藤, 正彦
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)The aryl hydrocarbon receptor (AHR) is a dioxin receptor that activates the differentiation of T helper 17 (Th17) cells and regulatory T (Treg) cells to produce interleukin-22 (IL-22). In whole exome sequence analysis, we found two single nucleotide polymorphisms (SNPs) in AHR, rs2074113 and rs2066853. In addition, we investigated the correlation between these AHR SNPs and susceptibility to psoriasis in 185 patients with psoriasis vulgaris (PV) and 145 healthy controls by using TaqMan® SNP Genotyping assays. For rs2074113, in both groups the frequency of the G allele was 0.59 and that of the T allele was 0.41. For rs2066853, in both groups the frequency of the A allele was 0.42 and that of the G allele was 0.58. Thus both allele frequencies in both groups were not significantly different and therefore the frequency of AHR SNPs and susceptibility to PV were not correlated. However, in a comparison of HLA-C^* 06:02-positive and -negative patients, rs2066853 AA homozygotes were significantly decreased in HLA-C^* 06:02-positive PV patients compared to HLA- C^* 06:02-negative PV patients after Bonferroni correction. These observations suggested that AHR rs2066853 may be a protective gene for psoriasis in the Japanese population.
本文言語eng
著者キーワードaryl hydrocarbon receptor
psoriasis vulgaris
single nucleotide polymorphism
disease susceptibility to psoriasis
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
63
3-4
開始ページ41
終了ページ48
発行日2016
著者版/出版社版出版社版
リポジトリIDA050063000302
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050063000302