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フルテキストURLA050063000104.pdf ( 1.8MB ) 公開日 2016-09-23
タイトルAngiotensin II increases oxidative stress and induces glomerular sclerosis via toll-like receptor 4
作成者Okamoto, Tadashi
Umemoto, Seiji
Yoshimura, Koichi
Sakumura, Toshihiro
Murata, Tomoaki
Fukai, Tohru
Yano, Masafumi
Matsuzaki, Masunori
作成者ヨミオカモト, タダシ
ウメモト, セイジ
ヨシムラ, コウイチ
サクムラ, トシヒロ
ムラタ, トモアキ
フカイ, トオル
ヤノ, マサフミ
マツザキ, マスノリ
作成者別表記岡本, 匡史
梅本, 誠治
吉村, 耕一
作村, 俊浩
村田, 智昭
深井, 透
矢野, 雅文
松﨑, 益徳
作成者所属山口大学大学院医学系研究科(医学)
山口大学総合科学実験センター
内容記述(抄録等)Background: Angiotensin II (AngII) increases reactive oxygen species (ROS) and induces glomerular sclerosis. Toll-like receptor 4 (TLR4)-mediated inflammation enhances the renal impairment in renal inflammatory diseases. The relationship between TLR4 and AngII-induced glomerular sclerosis is unknown.Methods: Mice lacking TLR4 function (Tlr4^{lps-d}) and wild-type (WT) mice were randomized into groups treated with AngII, norepinephrine (NE) or a sub-depressor dose of the AngII receptor blocker irbesartan along with AngII for 2 weeks. We then assessed the expressions of NADPH oxidase and monocyte chemoattractant protein-1 (MCP-1) and the inflammatory cell recruitment in the glomeruli. We also evaluated the mesangial matrix proliferation and ROS.Results: AngII and NE equally increased the systolic blood pressure compared to the control mice (p<0.05). In the WT mice treated with AngII, we observed glomerular sclerosis, an increase in NADPH oxidase, MCP-1 and the infiltration of macrophages as well as ROS content in the glomeruli compared to the control mice (p<0.05), whereas the Tlr4^{lps-d} mice showed little effects of AngII on these indices. In addition, the sub-depressor-dose irbesartan treatment reversed these changes. NE had little effects on these indices. Conclusions: TLR4 plays an important role in AngII-induced oxidative stress, inflammation and glomerular sclerosis through the AT1 receptor.
本文言語eng
著者キーワードglomerular sclerosis
oxidative stress
inflammation
monocyte chemoattractant protein-1
angiotensin II
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
63
1-2
開始ページ25
終了ページ34
発行日2016
著者版/出版社版出版社版
リポジトリIDA050063000104
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050063000104