Japanese | English

トップページへ戻る

詳細

   
フルテキストURLA050063000103.pdf ( 462.0KB ) 公開日 2016-09-23
タイトルMicrobial contamination of in-use ophthalmic preparations and its prevention
作成者Saisyo, Atsuyuki
Oie, Shigeharu
Kimura, Kazuhiro
Sonoda, Koh-Hei
Furukawa, Hiroyuki
作成者ヨミサイショ, アツユキ
オイエ, シゲハル
キムラ, カズヒロ
ソノダ, コウヘイ
フルカワ, ヒロユキ
作成者別表記税所, 篤行
尾家, 重治
木村, 和博
園田, 康平
古川, 裕之
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)Aims: To clarify the usefulness of preservative-free ophthalmic preparations equipped with a filter. Methods: A total of 1,615 samples of in-use ophthalmic preparations were examined for microbial contamination. Results: Of 1,094 samples of preservative-containing ophthalmic preparations, 31 (2.8%) showed microbial contamination. Of 289 samples of preservative-free ophthalmic preparations without a filter, 6 (2.1%) were contaminated, consisting of 4 (13.8%) of 29 samples of hospital preparations and 2 (0.8%) of 260 samples of commercially available new quinolone antimicrobial agents. On the other hand, the microbial contamination rate in preservative-free ophthalmic preparations equipped with a filter was 0% (0 of 232 samples).The major contaminants detected in these preservative-containing ophthalmic preparations and preservative-free ophthalmic preparations without a filter were glucose-nonfermentative Gram-negative bacilli such as Pseudomonas fluorescens, Acinetobacter spp., and P. aeruginosa, coagulase (-) staphylococci, and Candida spp. The contaminant level was 10-99 colony forming units (CFU)/mL in 37.8% (14 of 37 samples), and 10^2 - 10^6 CFU/mL in 62.2% (23 of 37 samples). Conclusions: Preservative-free ophthalmic preparations equipped with a filter not only have zero risk of the oculotoxic effects of preservatives, but are also safe in terms of their lack of microbial contamination.
本文言語eng
著者キーワードophthalmic preparation
multiple-dose
preservative
filter
microbial contamination
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
63
1-2
開始ページ17
終了ページ24
発行日2016
著者版/出版社版出版社版
リポジトリIDA050063000103
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050063000103