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フルテキストURLA050063000102.pdf ( 661.2KB ) 公開日 2016-09-23
タイトルRelationship between the myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy
作成者Oda, Seiko
Kobayashi, Shigeki
Nanno, Takuma
Ishiguchi, Hironori
Myoren, Takeki
Murakami, Wakako
Mochizuki, Mamoru
Oda, Tetsuro
Okuda, Shinichi
Yamada, Jutaro
Okamura, Takayuki
Matsuzaki, Masunori
Yano, Masafumi
作成者ヨミオダ, セイコ
コバヤシ, シゲキ
ナンノ, タクマ
イシグチ, ヒロノリ
ミョウレン, タケキ
ムラカミ, ワカコ
モチヅキ, マモル
オダ, テツロウ
オクダ, シンイチ
ヤマダ, ジュタロウ
オカムラ, タカユキ
マツザキ, マスノリ
ヤノ, マサフミ
作成者別表記小田, 聖子
小林, 茂樹
南野, 巧真 
石口, 博智
明連, 武樹
村上, 和華子
望月, 守
小田, 哲郎
奥田, 真一
山田, 寿太郎
岡村, 誉之
松﨑, 益徳
矢野, 雅文
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)We investigated the relationship between myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy (TC) compared with acute anteroseptal myocardial infarction (AMI). Methods: In 10 TC patients and 10 AMI patients, electrocardiogram, echocardiography, cardiac catheterization were conducted, and plasma catecholamines and urinary (U) 8-hydroxy-2’-deoxyguanosine (8-OHdG) as a marker of oxidative DNA damage were taken for one week from onset. Results: On admission, the coronary sinus (CS) had significantly higher norepinephrine (NE) and 8-OHdG levels than the aortic root (Ao) and peripheral blood vessels. Circulating catecholamines in TC patients tended to be higher than those in AMI patients; especially, peripheral plasma NE levels (day 1) in patients with TC were significantly higher than those in patients with AMI. TC patients had elevated U-8-OHdG in parallel with elevated NE, whereas, AMI patients had U-8-OHdG level that decreased to almost normal range within one week. On day 1, in patients with TC, serum 8-OHdG differences (CS vs Ao) and U-8-OHdG increased proportionally with the wall-motion score as an index of LV dysfunction, whereas serum NE (CS vs Ao) did not. Conclusion: Myocardial oxidative stress induced by cardiac sympathetic hyperactivity may play a critical role in transient LV dysfunction in TC.
本文言語eng
著者キーワードtakotsubo cardiomyopathy
oxidative stress
catecholamine
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
63
1-2
開始ページ5
終了ページ16
発行日2016
著者版/出版社版出版社版
リポジトリIDA050063000102
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050063000102