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フルテキストURLA050063000101.pdf ( 507.3KB ) 公開日 2016-09-23
タイトルAn invited review following the soujinkai young investigator award : Heat shock factor 1 could be a promising new therapeutic target for melanoma
作成者Nakamura, Yoshitaka
Nakai, Akira
Muto, Masahiko
作成者ヨミナカムラ, ヨシタカ
ナカイ, アキラ
ムトウ, マサヒコ
作成者別表記中村, 好貴 
中井, 彰
武藤, 正彦
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)Heat shock factor 1 (HSF1) has recently been reported to promote malignant transformation and growth. Furthermore, HSF1 was identified as a potent proinvasion oncogene in human melanomas. However, the biological functions of HSF1 in human melanoma remain poorly understood. In this study, we found that silencing HSF1 suppressed proliferation, migration and invasiveness of human melanoma cells in vitro and HSF1 is required for melanoma invasion and metastasis, as well as tumorigenic potential in vivo. Furthermore, we demonstrated that these decreased functions by HSF1 knockdown were restored by overexpression of wild-type HSF1 both in vitro and vivo. Our findings suggest that HSF1 could be a promising new therapeutic target for melanoma.This article is an invited review by the awardee of the Soujinkai Young Investigator Award, based on his original paper published in Cancer Letters in 2014.
本文言語eng
著者キーワードhuman melanoma
heat shock factor 1 (hsf1)
proliferation
migration
invasion
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
63
1-2
開始ページ1
終了ページ4
発行日2016
著者版/出版社版出版社版
リポジトリIDA050063000101
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050063000101