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タイトルClonidineとMuscimolの併用投与によるGnawing(かじり)反応への中枢Dopamine神経系の関与について
タイトルヨミClonidine ト Muscimol ノ ヘイヨウ トウヨ ニ ヨル Gnawing カジリ ハンノウ エ ノ チュウスウ Dopamine シンケイ ケイ ノ カンヨ ニ ツイテ
タイトル別表記Involvement of nigrostriatal dopaminergic system in the gnawing behaviors induced by clonidine plus muscimol in mice
作成者兼行, 浩史
牛島, 逸子
浮田, 孟
水木, 泰
山田, 通夫
作成者ヨミカネユキ, ヒロシ
ウシジマ, イツコ
ウキタ, タケシ
ミズキ, ヤスシ
ヤマダ, ミチオ
作成者別表記Kaneyuki, Hiroshi
Ushijima, Itsuko
Ukita, Takeshi
Misuki, Yasushi
Yamada, Michio
作成者所属山口大学医学部
内容記述(抄録等)The neurochemical and behavioral studies were carried out to clarify the neuronal mechanisms involved in the stereotype gnawing behaviors induced by clonidine (as an adenosine antagonist) plus muscimol (a GABA-a agonist) in mice. Combined treatment of clonidine (20mg/kg ip) and muscimol (0.5mg/kg ip) significantly increased 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels in the dosal striatum as compared with saline group. Conversely, DOPAC levels in the medial prefrontal cortex tended to decrease, but not significantly. There was no significant change in serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels among any regions. The frequency of gnawing behaviors was proportional to the dose of muscimol (0.25-1.0mg/kg), but not to that of clonidine (20-40mg/kg). Gnawing behaviors were hardly produced by muscimol (0.5mg/ kg) or clonidine (20mg/kg) alone. Haloperidol (0.1, 0.2mg/kg ip), but neither bisusulline (1.0-3.0mg/kg ip ; a GABA-a antagonist) nor picrotoxin (0.5-1.5mg/kg ip ; a chloride channel brocker), inhabited gnawing behaviors induced by clonidine (20mg/kg) plus muscimol (0.5mg/kg). These results suggest that the activition of nigrostriatal dopamine (DA) neurons, but not mesoprefrontal DA neurons, may be involved in the grawing behaviors induced by combined treatment of clonidine and muscimol. The role of muscimol in producing gnawing behaviors may not be due to the stimulation of GABA-a receptors.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
40
5
開始ページ541
終了ページ549
発行日1991-10
著者版/出版社版その他
リポジトリIDB030040000504
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030040000504