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フルテキストURLA050062000306.pdf ( 993.2KB ) 公開日 2016-05-20
タイトルDuration of prophylaxis against venous thromboembolism with low molecular weight heparin (enoxaparin) after surgery for abdominal and esophageal cancer : a single institution, prospective, randomized trial in japan
作成者Katsura, Shunsaku
Enoki, Tadahiko
Kugimiya, Naruji
Takemoto, Yoshihiro
Oka, Kazuhito
Harada, Eijiro
Hamano, Kimikazu
作成者ヨミカツラ, シュンサク
エノキ, タダヒコ
クギミヤ, ナルジ
タケモト, ヨシヒロ
オカ, カズヒト
ハラダ, エイジロウ
ハマノ, キミカズ
作成者別表記桂, 春作
榎, 忠彦
釘宮, 成二
竹本, 圭宏
岡, 一斉
原田, 栄二郎
濱野, 公一
作成者所属山口大学大学院医学系研究科(医学)
内容記述(抄録等)Background: The optimal duration of thromboprophylaxis after surgery for cancer has not been clearly defined in Japan. The aim of this prospective study was to evaluate the efficacy and safety of 3 days of thromboprophylaxis in comparison to 10 days of thromboprophylaxis with low molecular weight heparin (enoxaparin) in patients undergoing elective surgery for abdominal and esophageal cancer.Methods: The study population included patients who were over 40 years of age and who were planning to undergo elective surgery for abdominal and esophageal cancer. 101 patients were randomly assigned to the short thromboprophylaxis (3 days) and long thromboprophylaxis (10 days) groups. Finally, after applying the exclusion criteria, we evaluated 45 patients in each group. The primary efficiency endpoint was the incidence of venous thromboembolism between day 11 and the day of discharge.Results: The incidence rates of distal deep vein thrombosis (DVT) after surgery were 6.7% and 8.9% in the short and long thromboprophylaxis groups, respectively. (p = 0.50). There was no significant difference. Conclusions: We concluded that if pharmacological thromboprophylaxis with enoxaparin was combined with mechanical methods in patients undergoing elective surgery for cancer, then the adequate duration of routine thromboprophylaxis with enoxaparin was only 3 days.
本文言語eng
著者キーワードlow molecular weight heparin
enoxaparin
venous thromboembolism
surgery
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
62
3-4
開始ページ59
終了ページ65
発行日2015
著者版/出版社版出版社版
リポジトリIDA050062000306
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050062000306