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フルテキストURLA050062000304.pdf ( 871.7KB ) 公開日 2016-05-20
タイトルAn invited review following the soujinkai fujiu memorial award : Involvement of oxidative stress in the pathophysiology of varicocele
作成者Shiraishi, Koji
作成者ヨミシライシ, コウジ
作成者別表記白石, 晃司
作成者所属山口大学医学部附属病院
内容記述(抄録等)A varicocele is an abnormal dilatation of the pampiniform plexus within the spermatic cord and is the most common and treatable cause of male infertility, with a variety of etiologies. Varicocelectomy increases the fertilization, pregnancy and live birth rates, indicating improved sperm function; it is therefore important even in couples undergoing intracytoplasmic sperm injection. However, despite ongoing extensive research on varicoceles, the exact mechanisms by which varicocele influences male infertility is not fully understood. Recent studies have shown that infertile men with varicocele have higher levels of oxidative stress (OS), and/or lower seminal antioxidant levels, than do fertile men and infertile men without varicocele. Heat stress has been shown as one of the most possible causes. The abnormally high levels of seminal OS biomarkers in infertile men with varicocele is clinically relevant as these markers have been associated with poor sperm function and reduced fertility potential. In addition, infertile patients with varicocele possess high levels of sperm DNA damage is believed to be at least in part due to OS. The observed improvement in seminal OS, spermatogenesis and sperm DNA damage after varicocelecotmy supports the premise that varicocele can induce seminal OS.
本文言語eng
著者キーワードvaricocele
male infertility
oxidative stress
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
62
3-4
開始ページ47
終了ページ54
発行日2015
著者版/出版社版出版社版
リポジトリIDA050062000304
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050062000304