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タイトルCyclosporine A による冠動脈、頸動脈、腹部内臓分枝動脈内膜肥厚抑制効果の検討
タイトルヨミCyclosporine A ニヨル カンドウミャク ケイドウミャク フクブ ナイゾウ ブンシ ドウミャク ナイマク ヒコウ ヨクセイ コウカ ノ ケントウ
タイトル別表記Inhibitory Effect of Cyclosporine on Intimal Thickening in the Coronary Arteries, Carotid Arteries and the Branches of Abdominal Aorta in the Rabbits Fed High Cholesterol Diet
作成者原田, 幹彦
藤岡, 顕太朗
江里, 健輔
作成者ヨミハラダ, ミキヒコ
フジオカ, ケンタロウ
エサト, ケンスケ
作成者別表記Harada, Mikihiko
Fujioka, Kentarou
Esato, Kensuke
作成者所属山口大学医学部
内容記述(抄録等)We investigated the effect of cyclosporine A (CYA). an immunosuppressant, on intimal thickening of the arteries induced in 12 rabbits fed high-cholesterol diet. A control group (n=4) received commercial rabbit chow; a cholesterol group (n=4) received rabbit chow with % cholesterol: and a cyclosporine group (n=4) received the cholesterol diet plus cyclosporine 5mg/kg daily subcutaneously. All animals were killed 3 months after the beginning of the experiment, and the coronary artery, the carotid artery and the branch of the abdominal aorta were removed. Specimens were fixed in 10% formaldehyde, embedded in paraffin, cut along the transversal axis. Intraluminal space and intimal area of each artery were measured. Vessel stenotic rate was obtained by dividing the intraluminal space by the intraluminal space plus the intimal area and multiplying by 100. Vessel stenotic rate in coronary artery was 0% in the control group, 49±15% in the cholesterol group, 0% in the CYA group. This rate in carotid artery compared among the control, cholesterol and CYA group was 0%, 30±14%, and 47±16%, respectively. This rate in branche of abdominal aorta in the control, cholesterol, and CYA group was 0%, 6±5%, and 6±5%, respectively. There was statistically significant difference in the vessel stenotic rate of the coronary artery between the cholesterol and the control, and also between the cholesterol and CYA group (p<0.05). We concluded that cyclosporine inhibits intimal thickening of the coronary artery in the rabbits fed high-cholesterol diet.
本文言語jpn
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
41
5
開始ページ319
終了ページ322
発行日1992-10
著者版/出版社版その他
リポジトリIDB030041000501
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030041000501