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フルテキストURLA020052000102.pdf ( 254.2KB ) 公開日 2010-04-19
タイトルA Case of Therapy-resisutant Idipathic Hypereosinophilic Syndrome with Severe Disseminated Instravascular Coagulation
作成者Takahashi, Toru
Fukuda, Naoki
Sato, Yutaka
Tanizawa, Yukio
作成者ヨミタカハシ, トオル
フジタ, ナオキ
サトウ, ユタカ
タニザワ, ユキオ
作成者所属山口大学医学部
内容記述(抄録等)Dissaminated intravascular coagulation (DIC) is a rare complication of idiopathic hypereosinophilic syndorome (HES). We report a case of therapy-resistant HES complicated with DIC, in which the sequential profile of vascular endothelial adhesion molecule, eosinophil granule proteins, and several cytokines during clinical course were observed. Serum proteins derived from eosinophil granule and serum soluble vascular cell adhesion molecule 1 had elevated and fluctuated along with the eosinophilia and DIC. The level of serum tumor necrosis factor-α, which stimulates eosinophil attachment to endothelium, was also high in overt DIC. These findings suggest that there may be strong interactions between eosinophils and vascular endothelium and that adhernce of eosinophils to endothelium and production of eosinophil granule proteins may contribute to the development of DIC in HES.
本文言語eng
著者キーワードhypereosinophilic syndrome
disseminated intravascular coagulation
eosinophil granule proteins
cytokines
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
52
1-2
開始ページ15
終了ページ19
発行日2005-06
著者版/出版社版出版社版
リポジトリIDA020052000102
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020052000102