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フルテキストURLA050062000101.pdf ( 880.1KB ) 公開日 2015-09-17
タイトルSystemic inflammation and delirium in the periextubation period of mechanical ventilation : an observational prospective study of intensive care unit patients
作成者Ogino, Yasuaki
Kaneda, Kotaro
Nakahara, Takashi
Todani, Masaki
Miyauchi, Takashi
Fujita, Motoki
Kawamura, Yoshikatsu
Oda, Yasutaka
Tsuruta, Ryosuke
作成者ヨミオギノ, ヤスアキ
カネダ, コウタロウ
ナカハラ, タカシ
トダニ, マサキ
ミヤウチ, タカシ
フジタ, モトキ
カワムラ, ヨシカツ
オダ, ヤスタカ
ツルタ, リョウスケ
作成者別表記荻野, 泰明
金田, 浩太郎
中原, 貴志
戸谷, 昌樹
宮内, 崇
藤田, 基
河村, 宜克
小田, 泰崇
鶴田, 良介
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)Background: Delirium is a common problem in intensive care units (ICUs) and is associated with poor outcomes. The association between inflammation and delirium in the peri-extubation period of mechanical ventilation (MV) is poorly understood. Methods: We conducted a prospective, observational study of adult patients on MV for >48 hours in an ICU. At extubation (0 h) and 24 h later, the Confusion Assessment Method for the ICU (CAM-ICU) and the following serum biomarkers were assessed:C-reactive protein (CRP), procalcitonin, white blood cell (WBC) count, interleukin (IL)-6 and -8. Patients were classified into delirious (D; at least one positive CAM-ICU) and nondelirious (N; negative CAM-ICU at both times) groups. Results: Of the 28 enrolled patients, 12 were in group D, and 16 were in group N. Patient characteristics were not different except for the Acute Physiology and Chronic Health Evaluation II score and Sequential Organ Failure Assessment score at 0 h. At 24 h, procalcitonin and IL-6 levels were higher in group D. During the 24-h period,CRP, IL-6, and IL-8 levels decreased in group N, and WBC count increased in group D. Conclusions: The results indicate an association between prolonged inflammation and delirium in the peri-extubation period of MV.
本文言語eng
著者キーワードdelirium,
mechanical ventilation
Confusion Assessment Method for the Intensive Care Unit
inflammation
C-reactive protein
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
62
1-2
開始ページ1
終了ページ10
発行日2015
著者版/出版社版出版社版
リポジトリIDA050062000101
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050062000101