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フルテキストURLA050061000302.pdf ( 1.8MB ) 公開日 2015-04-13
タイトルPrefrontal abnormality in children with adhd during cognitive interference control : a functional nirs study
作成者Nakashima, Mami
Matsuo, Koji
Hashimoto, Akiko
Nakano, Masayuki
Fujii, Yuko
Matsushige, Takeshi
Egashira, Kazuteru
Matsubara, Toshio
Nishida, Atsushi
Ichiyama, Takashi
Sugiyama, Shinsaku
Watanabe, Yoshifumi
作成者ヨミナカシマ, マミ
マツオ, コウジ
ハシモト, アキコ
ナカノ, マサユキ
フジイ, ユウコ
マツシゲ, タケシ
エガシラ, カズテル
マツバラ, トシオ
ニシダ, アツシ
イチヤマ, タカシ
スギヤマ, シンサク
ワタナベ, ヨシフミ
作成者別表記松尾, 幸治
橋本, 亜希子
藤井, 優子
松重, 武志
松原, 敏郎
渡邉, 義文
作成者所属山口大学大学院医学系研究科(医学)
山口大学医学部附属病院
山口大学大学教育機構
内容記述(抄録等)Aim: Children with attention-deficit/hyperactivity disorder (ADHD) show cognitive impairments such as disrupted attention and impaired learning and memory. The multi-source interference task (MSIT) combines multiple dimensions of cognitive interference and recruits the cingulo-frontal-parietal cognitive/attention network. The aim of this study was to determine whether children with ADHD show fronto-parietal dysfunction during the MSIT by using functional near-infrared spectroscopy (NIRS). Methods: Nineteen boys with ADHD and 14 age- and IQ-matched controls were studied. We measured oxygenated hemoglobin concentration ([oxy-Hb]) changes in the fronto-parietal region by using a 46-channel functional NIRS imaging system. The behavioral performance and mean [oxy-Hb] of the two groups during the MSIT were compared.Results: The behavioral data of the MSIT were not significantly different between the two groups. Compared to the control group, the ADHD group showed higher [oxy-Hb] changes in the left dorsolateral prefrontal region (ADHD, 0.17 × 10^-1 ±0.11; control, -0.65 × 10^-1 ± 0.62 ×10^-1; P = 0.02). Conclusion: Our results suggest that compared to controls, children with ADHD have abnormal prefrontal activation in response to multiple interference control, in order to achieve favorable outcomes of cognitive demand. These findings may provide insights into the pathophysiology of ADHD.
本文言語eng
著者キーワードattention-deficit/hyperactivity disorder
dorsolateral prefrontal cortex
hemodynamic response
multi-source interference
near-infrared spectroscopy
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
61
3-4
開始ページ37
終了ページ47
発行日2014
著者版/出版社版出版社版
リポジトリIDA050061000302
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050061000302