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フルテキストURLA020043000312.pdf ( 1.7MB ) 公開日 2010-04-19
タイトルComparative Effects of Angiotensin II Type 1 Receptor Blockade with Angiotensin-Converting -Enzyme Inhibitor on Aortic Smooth Muscle Cell Phenotype in Spontaneously Hypertensive Rats
作成者Fujii, Akihisa
作成者ヨミフジイ, アキヒサ
作成者所属山口大学医学部
内容記述(抄録等)To clarify the effects of renin-angiotensin system inhibition on aortic smooth muscle cell phennotype and fibrosis in spontaneously hypertensive rats (SHR), we treated 14-week -old SHR with a selective angiotensin II type 1 (AT1) receptor blockade, FK-739 (30mg/kg day) or sngiotensin-converting-enzyme (ACE) inhibitor, enalapril (10mg/kg/day) for 6 weeks. Both FK-739 and enalapril caused a significant decrease in blood pressere (p < 0.001) with no difference between the treated groups. Immunoblot showed no significant decrease in the expression of smooth muscle cell myosin heavy chain and nonmuscle myosin heavy chain (NMHC)-A in SHR aorta. In contrast, both FK- 739 and enalapril resulted in s significant decrease in the expression of NMHC-B compared with vehicle (vehicle vs FK-739 treated group ; p < 0.0001, vehicle vs enalapril treated group ; p < 0.025, respectively). Furthermore, FK-739 inhibited the expression of NMHC-B more significantly than enalapril statically among three groups. These results suggest that, compared with ACE inhibition, AT1 receptor blockade may have a more potent effect on the phenotype change of smooth muscle cell in SHR sorta.
本文言語eng
著者キーワードAngiotensin II type 1 receptor blockade
Smooth muscle cell
Myosin heavy chain isoform
Fibrosis
Hypertension
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
43
3-4
開始ページ117
終了ページ125
発行日1996-12
著者版/出版社版出版社版
リポジトリIDA020043000312
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020043000312