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フルテキストURLA020042000307.pdf ( 551.5KB ) 公開日 2010-04-19
タイトルEffects of Hepatic Denervation on Inchemia-Reperfusion of the Dogs Liver
作成者Hiraki, Sakurao
作成者ヨミヒラキ, サクラオ
作成者所属山口大学医学部
内容記述(抄録等)To investigate the role of the hepatic nerves in ischemia-reperfusion of the liver, we compared hepatic midro-hemodynamics in a denevervated liver model to that in the normal liver. The liver was reperfused after total hepatic ischemia for 30 minnutes. Hepatic tissue blood flow, index of oxygen saturation, and hemoglobin concentration were measered continuously from 5 minutes before clamping to 120 minutes after reperfusion. In the very early phase following reperfusion (at 1, 2, and 3 minutes), the hepatic tissue blood flow was significantly higher in the denervated group (P<0.05). At 2 minutes (P<0.01) and at 3, 5, and 15 minutes (P<0.05), the index of oxygen saturation in the denervated group was significantly higher. Rapid increaseing blood inflow after repertion was observed, possibly due to impairment of intrahepatic microcirculatory regulation caused by denervation. This suggests that the rapid blood inflow during reperfusion after ischemia may modify the reperfusion injury of the transplanted liver grafts.
本文言語eng
著者キーワードHepatic Denervation
Ischemia-Reperfusion
Liver Transplantation
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
42
3-4
開始ページ87
終了ページ92
発行日1995-12
著者版/出版社版出版社版
リポジトリIDA020042000307
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020042000307