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フルテキストURLA020041000304.pdf ( 1.4MB ) 公開日 2010-04-19
タイトルExperimental Brain Tumor Response to Hyperthermia Evaluated by in vivo 31P Magnetic Resonance Spectoscopy
作成者Kin, Shigenari
作成者ヨミシゲナリ, キン
作成者所属山口大学医学部
内容記述(抄録等)In vivo 31P-MR spectroscopy was employed to measure the energy metabolism and pH of T9 gliosarcomas in the flank of Fisher rats before and serially up to 24 h after hyperthermia at various temperatures. Water bath hyperthermia was used to heat tumors at 41℃, 43℃ and 45℃ for 30 min. Following hyperthermia at 41℃ , the ratio of β-nucleoside triphosphate to inorganic phosphate (β-NTP/Pi) significantly decreased at 1 h and 3 h (p<0.05), but recovered at 6 h. The-β-NTP/Pi ratio after hyperthermia at 43℃ and 45℃ decreased significantly up to 24 h (p<0.05). The intracellular pH significantly decreased from the pretreatment level at 6 h after hyperthermia at 45℃. Histological comparison of tumors with and without hyperthermia 24 h posttreatment showed the loss of the endothelial lining and enlargement of the interstitial space in tumors with hyperthermia at 43℃ and 45℃. Thrombosis in vessele and pyknosis were also demonstrated in tumors treated at 43℃ and 45℃. But these changes were more marked in tumors with hyperthermia at 45℃. Our data suggest that in vivo 31P-MR spectroscopy provides useful information about the therapeutic effects of hyperthermia within 6 h after the treatment.
本文言語eng
著者キーワードGenetic tolerance
F1 hybrid
Lymphocyte in tolerance
Fast green histone
Semiallogenic graft
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
41
3-4
開始ページ73
終了ページ80
発行日1994-12
著者版/出版社版出版社版
リポジトリIDA020041000304
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020041000304