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フルテキストURLA050061000101.pdf ( 1.5MB ) 公開日 2014-09-29
タイトルPathology of the inner ear after acoustic injury
作成者Kanagawa, Eiju
Sugahara, Kazuma
Hirose, Yoshinobu
Mikuriya, Takefumi
Shimogori, Hiroaki
Yamashita, Hiroshi
作成者ヨミカナガワ, エイジュ
スガハラ, カズマ
ヒロセ, ヨシノブ
ミクリヤ, タケフミ
シモゴオリ, ヒロアキ
ヤマシタ, ヒロシ
作成者別表記菅原, 一真
廣瀬, 敬信
御厨, 剛史
下郡, 博明
山下, 裕司
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)We examined the impact of acoustic injury on the cochlea by assessing auditory brain-stem response (ABR) threshold shifts, outer hair cells, and the number of synaptic ribbons before and after noise exposure. The ABR threshold was elevated immediately after noise exposure, but recovered over time; 14 days after noise exposure,the ABR threshold was approximately 15 dB higher than before exposure.There were few damaged outer hair cells. The number of synapses directly under inner hair cells markedly decreased immediately after noise exposure, but then exhibited early signs of recovery. Twenty-four hours after noise exposure, the number of synapses was higher than before exposure. Subsequently, synapse number decreased. Seven days after noise exposure, synapes number was lower than before exposure. In this acoustic injury model, although the synapses were damaged, as described in the previous reports on the temporary threshold shift (TTS), the regeneration of synapses was promoted soon thereafter. There appears to be a point during the repair process when the number of synapses temporarily increases. This model is considered to be a partially reversible synaptic damage model. This study revealed an association between the intensity of noise exposure and the severity of functional and histological damage.
本文言語eng
著者キーワードsynaptic ribbons
noise exposure
temporary threshold shift
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
61
1-2
開始ページ1
終了ページ6
発行日2014
著者版/出版社版出版社版
リポジトリIDA050061000101
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050061000101