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フルテキストURLA020041000310.pdf ( 1.9MB ) 公開日 2010-04-19
タイトルUltrastructural Investigation of Neuronal Damage induced by Interstitial Radiofrequency Hyperthermia in Adult Dogs
作成者Tsuchida, Eiji
Ikeda, Norio
Akimura, Tatuo
Kameda, Hideki
Ito, Haruhide
Matsuda, Tadayoshi
作成者ヨミツチダ, エイジ
イケダ, ノリオ
アキムラ, タツオ
カメダ, ヒデキ
イトウ, ハルヒデ
作成者所属山口大学医学部
内容記述(抄録等)A study was conducted using electron microscopy to investigate hyperthermia-induced damage to neurons and myelinated nerve tracts in order to determine the thermal threshold. Twenty adult dogs were used. After parietal craniectomy, four electrode meedles connected to a Thermotron-RF8 for interstitial 8-MHz radiofrequency hyperthermia were inserted in a 1 cm square pattern and placed at a depth of 1.5 cm from the brain surface. One thermocouple microprobe was set in the center of the square formed by the electrodes. One hour after heating for 15, 30, 45 and 60 minutes with set temperatures of 42℃ and 43℃, the animal's a brain was removed and the ultrastructural investigation was performed. The findings suggested that the normal brain adjacent to a tumor in vivo would be damaged irreversibly by a large thermal dose, and that neurons showed ultrastructura changes such as swollen or empty of mitochondria and central chromatolysis even after small and moderate thermal doses.
本文言語eng
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
41
3-4
開始ページ143
終了ページ148
発行日1994-12
著者版/出版社版出版社版
リポジトリIDA020041000310
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020041000310