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フルテキストURLA020041000308.pdf ( 1.0MB ) 公開日 2010-04-19
タイトルModulation of Ischemic Neuronal Death by Non-lethal Ischemia and Ubiquitin Reappearance in Gerbils
作成者Iwamoto, Tetsuaki
作成者ヨミイワモト, テツアキ
作成者所属山口大学医学部
内容記述(抄録等)Tolerance to lethal ischemia can be induced in gerbils by prior subjection to non-lethal ischemia. The sequential changes og ubiquitin immunoreactivity in the hippocampi of gerbils subjected to non-lethal ischemia followed by lethal ischemia were investigated. The double-ischemic group was subjected to non-lethal ischemia followed by lehtal ischeima, the single-ischemic group was subjected to lethal ischemia, only, the sham-ischemic qroup was subjected to sham operation followed by lethal ischemia. The densities of the CA (Cornu ammonis) 1 neurons were assessed by hematoxylin-eosin staining. In the double-ischemic group, the extent of the neuronal damage was less than that in the single-ischemic and sham ischemic groups (both P<0.02) and half that in the control group (P<0.002). Ubiquitin immunoreactivity (UIR) disappeared once after lethal ischemia in all the ischemic group (P<0.002). Ubiquitin immunoreactivity (UIR) disappeared once after lethal ischemia in all the ischemic groups. In the single and sham ischemic groups, UIR never reappeared, whereas in the double-ischemic group, it recovered partially during the early postischemic period and almost completely in the surviving cells eventually. Non-lethal ischemia reduces the ischemic damage caused by subsequent lethal ischemia in the Cai neurons of gerbils, and ubiquitination is related to the damage reduction.
本文言語eng
著者キーワードInactivation
HIV
Oral antiseptics
Povidone-iodine
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
41
3-4
開始ページ105
終了ページ111
発行日1994-12
著者版/出版社版出版社版
リポジトリIDA020041000308
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020041000308