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タイトル1%コレステロール負荷家兎に関するACE阻害剤(Cilazapril)の血管内膜肥厚抑制効果
タイトルヨミ1パーセント コレステロール フカ カト ニ カンスル ACE ソガイザイ Cilazapril ノ ケッカンナイ ヒコウ ヨクセイ コウカ
タイトル別表記The Effect of Angiotensin Converting Enzyme on Intimal Thickness in Cholesterol- Fed Rabbit
作成者藤田, 雄司
作成者ヨミフジタ, ユウジ
作成者別表記Fujita, Yuji
作成者所属山口大学医学部
内容記述(抄録等)The purpose of this study is to evaluate the effect of angiotensin converting enzyme inhibitor cilazaprilon inhibiting intimal thickening in 1% cholesterol-fed rabbits. Twenty rabbits were divided into the following 2 groups. A control group was fed commercial rabbit chow supplemented with 1% cholesterol (n=10), and a treated group received the cholesterol diet with 1mg/kg/day of cilazapril (n=10). Three months after the experiment, blood pressure was measured under anesthesia, and the serum levels of total cholesterol and angiotensin II were determined. Luminal and intimal areas were separately measured in the left common carotid artery, the left coronary artery, the descending thoracic aorta, and the infra-renal abdominal aorta respectively. Blood pressure and the serum level of angiotensin II were significantly decreased in the treated group. Stenotic ratio (Luminal area / Luminal area + Intimal area) in the carotid artery was significantly decreased in the treated group than in the control, but was not changed at the coronary artery, the thoracic aorta and the abdominal aorta between the 2 groups. In the treated group, cilazapril reduced intimal thickening only in the carotid artery, but not in the other arteries. These results suggest that angiotensin converting enzyme inhibitor cilazapril inhibit intimal thickness in the carotid artery, and the inhibitory effect of cilazapril on intimal thickening might depend on different characteristics in the artery.
本文言語jpn
著者キーワードCilaapril
Angiotensin Converting Enzyme Inhibitor
Intimal Thickness
主題医学
資料タイプtext
出版者山口大学医学会
出版者ヨミヤマグチ ダイガク イガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0513-1731
NCIDAN00243156
学内刊行物(紀要等)山口医学
掲載誌名山口医学
44
4
開始ページ187
終了ページ194
発行日1995-08
著者版/出版社版その他
リポジトリIDB030044000402
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/B030044000402