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フルテキストURLA050060000301.pdf ( 4.7MB ) 公開日 2014-06-19
タイトルMechanisms of corneal damage associated with ocular surface inflammation
作成者Kimura, Kazuhiro
作成者ヨミキムラ, カズヒロ
作成者別表記木村, 和博
作成者所属山口大学医学部附属病院
内容記述(抄録等)The cornea is a transparent tissue composed of epithelial cells, stromal keratocytes embedded in collagen fibers, and endothelial cells. Inflammation at the ocular surface can damage the cornea, which may become swollen or scarred, resulting in a loss of its clarity. In particular, the barrier function of the corneal epithelium can be disrupted by ocular surface inflammation, leading to adverse effects on the structure and function of the corneal stroma. Various cytokines and chemokines contribute to the inflammatory response at the ocular surface, with the proinflammatory cytokines tumor necrosis factor–α (TNF-α) and interleukin-1β (IL-1β) in particular playing key roles in this response. Intercellular junctions such as adherens junctions, tight junctions, and gap junctions that form between adjacent corneal epithelial cells or stromal keratocytes are essential for the maintenance of corneal homeostasis. To provide insight into the mechanisms of corneal damage induced by inflammation, we have examined the effects of TNF-α and IL-1β on tight junctions and adherens junctions in cultured monolayers of human corneal epithelial cells as well as on gap junctions in cultured stromal keratocytes. We here review the results of our recent studies and their implications for the development of new approaches to ameliorate or prevent corneal disorders associated with ocular surface inflammation.
本文言語eng
著者キーワードtumor necrosis factor–α (TNF-α)
interleukin-1β (IL-1β)
tight junction
adherens junction
gap junction
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
60
3-4
開始ページ47
終了ページ55
発行日2013
著者版/出版社版出版社版
リポジトリIDA050060000301
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050060000301