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フルテキストURLA050060000103.pdf ( 437.0KB ) 公開日 2014-02-21
タイトルAprepitant relieves chemotherapy-induced inappetance in colorectal cancer patients in the acute phase of mod-erate emetogenic chemotherapy: An observational study based on self-report diaries
作成者Kaneko, Tadashi
Furuya, Takumi
Fujimoto, Takuya
Kamimura, Yoshio
Takemoto, Norikazu
Hayashi, Hideto
Yahara, Noboru
Inoue, Takeshi
Saeki, Toshihiro
Hayashi, Hiroto
作成者ヨミカネコ, タダシ
フルヤ, タクミ
フジモト, タクヤ
カミムラ, ヨシオ
タケモト, ノリカズ
ハヤシ, ヒデト
ヤハラ, ノボル
イノウエ, タケシ
サエキ, トシヒロ
ハヤシ, ヒロト
作成者所属山口大学医学部附属病院
内容記述(抄録等)Background: The novel drugs aprepitant (APR) and palonosetron are rec- ommended for the treatment of chemotherapy-induced nausea and vomiting. Here, we assessed the effects of these antiemetics using a self-report diary.Methods: This was a retrospective observational study based on data from 87 pa- tients spectively collected in 222 self-report diaries. We assessed the effect of vomiting and nausea on the patients'quality-of-life, and food and water intake. A“no event”was treated as a favorable outcome. We compared the rates of no event be-tween the first course of chemotherapy and subsequent courses, as well as among the different emetogenic risks and post-chemotherapy phases. We also studied the effect of APR in a subgroup of colorectal cancer patients receiving moderate emetogenic chemotherapy.Results: Nearly 90% of patients reported that the vomiting and nausea did not af- fect their quality-of-life; however, the rate of normal food intake was only 30%-40%. Colorectal cancer patients receiving APR demonstrated a significantly higher rate of normal food intake during the first chemotherapy course than those who did not re- ceive this drug.Conclusions: APR could relieve this chemotherapy-induced inappetance in colorectal cancer patients in the first course and acute phase of moderate emetogenic chemo-therapy.
本文言語eng
著者キーワードantiemesis
palonosetron
food intake
water intake
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
60
1-2
開始ページ19
終了ページ26
発行日2013
著者版/出版社版出版社版
リポジトリIDA050060000103
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050060000103