| フルテキストURL | A050060000103.pdf ( 437.0KB ) 公開日 2014-02-21
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| タイトル | Aprepitant relieves chemotherapy-induced inappetance in colorectal cancer patients in the acute phase of mod-erate emetogenic chemotherapy: An observational study based on self-report diaries |
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| 作成者 | Kaneko, Tadashi
Furuya, Takumi
Fujimoto, Takuya
Kamimura, Yoshio
Takemoto, Norikazu
Hayashi, Hideto
Yahara, Noboru
Inoue, Takeshi
Saeki, Toshihiro
Hayashi, Hiroto
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| 作成者ヨミ | カネコ, タダシ
フルヤ, タクミ
フジモト, タクヤ
カミムラ, ヨシオ
タケモト, ノリカズ
ハヤシ, ヒデト
ヤハラ, ノボル
イノウエ, タケシ
サエキ, トシヒロ
ハヤシ, ヒロト
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| 作成者所属 | 山口大学医学部附属病院
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| 内容記述（抄録等） | Background: The novel drugs aprepitant (APR) and palonosetron are rec- ommended for the treatment of chemotherapy-induced nausea and vomiting. Here, we assessed the effects of these antiemetics using a self-report diary.Methods: This was a retrospective observational study based on data from 87 pa- tients spectively collected in 222 self-report diaries. We assessed the effect of vomiting and nausea on the patients'quality-of-life, and food and water intake. A“no event”was treated as a favorable outcome. We compared the rates of no event be-tween the first course of chemotherapy and subsequent courses, as well as among the different emetogenic risks and post-chemotherapy phases. We also studied the effect of APR in a subgroup of colorectal cancer patients receiving moderate emetogenic chemotherapy.Results: Nearly 90% of patients reported that the vomiting and nausea did not af- fect their quality-of-life; however, the rate of normal food intake was only 30%-40%. Colorectal cancer patients receiving APR demonstrated a significantly higher rate of normal food intake during the first chemotherapy course than those who did not re- ceive this drug.Conclusions: APR could relieve this chemotherapy-induced inappetance in colorectal cancer patients in the first course and acute phase of moderate emetogenic chemo-therapy.
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| 本文言語 | eng
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| 著者キーワード | antiemesis
palonosetron
food intake
water intake
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University School of Medicine
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| NII資料タイプ | 紀要論文 |
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| ISSN | 0513-1812
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| NCID | AA00594272
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 巻 | 60 |
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| 号 | 1-2 |
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| 開始ページ | 19 |
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| 終了ページ | 26 |
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| 発行日 | 2013 |
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A050060000103 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050060000103 |
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