| フルテキストURL | A020033000104.pdf ( 700.2KB ) 公開日 2010-04-19
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| タイトル | Effects of Diazepam and Nitrazepam on Psychophysiological Functions in Normal Humans |
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| 作成者 | Mizuki, Yasushi
Hirano, Hitoshi
Miyoshi, Akira
Hamasaki, Junko
Yamada, Michio
Glavin, Gary B.
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| 作成者ヨミ | ミズキ, ヤスシ
ヒラノ, ヒトシ
ミヨシ, アキラ
ハマサキ, ジュンコ
ヤマダ, ミチオ
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| 作成者所属 | 山口大学医学部
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| 内容記述（抄録等） | The infuluence of dizepam and nitrazepam on arousal level, muscle strength, psychomotor performance and memory function using the photopalpebral reflex (PPR), critical flicker frequency (CFF), tapping test, (CRT) and mamory drum test (MDT) were investigated in the present study. The healtyv male universitv atudents were given diazepam 5 mg and 10 mg, and plecedo in a doubleblind, cross-over design. The tests and subjective assessments were performed before and after drug administration. All drugs produced a prolongation of PPR latencies and a decrease of CFF, and diazepam 10 mg and nitrazepam 10 mg were the most efficacious in producing these phenomena. Tapping rate increased after administration of all agents, and then decreased to control levels. PRT and CRT improved after all drugs and performance on these tasks was most improved by diazepam 10 mg. Memory tasks were impaired following administration of all drugs. No significant changes were observed in the assessments of the subjects. These results suggest that the physiological and psychological tests employed in this study are useful tools for assessing the residual effects of benzodiazepines in normal humans, and that small doses of benzodiazepines lower arousal level, impair memory, but improve motor and psychomotor performance.
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| 本文言語 | eng
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| 著者キーワード | Residual effects
Diazepam
Nitrazepam
Psychophysiological tools
Normal humans
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| 主題 | 医学
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University Graduate School of Medicine
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| NII資料タイプ | 紀要論文 |
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| ISSN | 0513-1812
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| NCID | AA00594272
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名別表記 | 山口医科大学紀要 |
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| 巻 | 33 |
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| 号 | 1 |
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| 開始ページ | 25 |
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| 終了ページ | 32 |
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| 発行日 | 1986-12 |
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A020033000104 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020033000104 |
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