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フルテキストURLA020033000104.pdf ( 700.2KB ) 公開日 2010-04-19
タイトルEffects of Diazepam and Nitrazepam on Psychophysiological Functions in Normal Humans
作成者Mizuki, Yasushi
Hirano, Hitoshi
Miyoshi, Akira
Hamasaki, Junko
Yamada, Michio
Glavin, Gary B.
作成者ヨミミズキ, ヤスシ
ヒラノ, ヒトシ
ミヨシ, アキラ
ハマサキ, ジュンコ
ヤマダ, ミチオ
作成者所属山口大学医学部
内容記述(抄録等)The infuluence of dizepam and nitrazepam on arousal level, muscle strength, psychomotor performance and memory function using the photopalpebral reflex (PPR), critical flicker frequency (CFF), tapping test, (CRT) and mamory drum test (MDT) were investigated in the present study. The healtyv male universitv atudents were given diazepam 5 mg and 10 mg, and plecedo in a doubleblind, cross-over design. The tests and subjective assessments were performed before and after drug administration. All drugs produced a prolongation of PPR latencies and a decrease of CFF, and diazepam 10 mg and nitrazepam 10 mg were the most efficacious in producing these phenomena. Tapping rate increased after administration of all agents, and then decreased to control levels. PRT and CRT improved after all drugs and performance on these tasks was most improved by diazepam 10 mg. Memory tasks were impaired following administration of all drugs. No significant changes were observed in the assessments of the subjects. These results suggest that the physiological and psychological tests employed in this study are useful tools for assessing the residual effects of benzodiazepines in normal humans, and that small doses of benzodiazepines lower arousal level, impair memory, but improve motor and psychomotor performance.
本文言語eng
著者キーワードResidual effects
Diazepam
Nitrazepam
Psychophysiological tools
Normal humans
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
33
1
開始ページ25
終了ページ32
発行日1986-12
著者版/出版社版出版社版
リポジトリIDA020033000104
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020033000104