| フルテキストURL | A020032000110.pdf ( 492.1KB ) 公開日 2010-04-19
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| タイトル | Antianxiety Effect of Ehtyl Loflazepate， CM6912， Assessed by Frontal Medline Theta Activity in Man |
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| 作成者 | Mizuki, Yasushi
Hirano, Hitoshi
Hamasaki, Junko
Ushijima, Itsuko
Yamada, Michio
Tanaka, Masatoshi
Inanaga, Kazutoyo
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| 作成者ヨミ | ミズキ, ヤスシ
ヒラノ, ヒトシ
ハマサキ, ジュンコ
ウシジマ, イツコ
ヤマダ, ミチオ
タナカ, マサトシ
イナナガ, カズトヨ
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| 作成者所属 | 山口大学医学部
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| 内容記述（抄録等） | The theta activity which appears in the frontal midline area during performance of mental tasks been designated as Fmθ. In the present atudy, the potency of CM6912 as an anixiolytic was investigated using Fmθas compared with diazepam. Sixteen male university students were given placebo, diazepam 5 mg, CM6912 2 mg and 4 mg in a double-blind, crossover design. Scores were made on the state anxiety scale of Spielberger`s State Trait Anxiety Inventory (STAI), EEDs were recorded before and during performance of an arithmetic addition. The test was repeated twice, before and 1 hr after drug administration. Placebo increased Fmθ ; however, diazepam, CM6912 4 mg only slightly influenced Fmθ. Scores of state anxiety were reduced by diazepam, placebo and CM6912 4 mg, and only slightly by CM6912 2 mg. Task performance was increased by placebo, but wads not affected by diazepam and both doses of CM6912. These results suggest that CM6912 possesses a rather mild anxiolytic effect, and that Fmθmight be a useful tool in precting the clinical efficacy of anxiolytic drugs in normal humans.
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| 本文言語 | eng
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| 著者キーワード | benzodiazepines
diazepam
CM6912
antianxiety effect
frontal midline theta activity (Fmθ）
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| 主題 | 医学
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University Graduate School of Medicine
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| NII資料タイプ | 紀要論文 |
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| ISSN | 0513-1812
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| NCID | AA00594272
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名別表記 | 山口医科大学紀要 |
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| 巻 | 32 |
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| 号 | 1 |
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| 開始ページ | 71 |
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| 終了ページ | 77 |
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| 発行日 | 1985-12 |
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A020032000110 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020032000110 |
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