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フルテキストURLA020032000110.pdf ( 492.1KB ) 公開日 2010-04-19
タイトルAntianxiety Effect of Ehtyl Loflazepate, CM6912, Assessed by Frontal Medline Theta Activity in Man
作成者Mizuki, Yasushi
Hirano, Hitoshi
Hamasaki, Junko
Ushijima, Itsuko
Yamada, Michio
Tanaka, Masatoshi
Inanaga, Kazutoyo
作成者ヨミミズキ, ヤスシ
ヒラノ, ヒトシ
ハマサキ, ジュンコ
ウシジマ, イツコ
ヤマダ, ミチオ
タナカ, マサトシ
イナナガ, カズトヨ
作成者所属山口大学医学部
内容記述(抄録等)The theta activity which appears in the frontal midline area during performance of mental tasks been designated as Fmθ. In the present atudy, the potency of CM6912 as an anixiolytic was investigated using Fmθas compared with diazepam. Sixteen male university students were given placebo, diazepam 5 mg, CM6912 2 mg and 4 mg in a double-blind, crossover design. Scores were made on the state anxiety scale of Spielberger`s State Trait Anxiety Inventory (STAI), EEDs were recorded before and during performance of an arithmetic addition. The test was repeated twice, before and 1 hr after drug administration. Placebo increased Fmθ ; however, diazepam, CM6912 4 mg only slightly influenced Fmθ. Scores of state anxiety were reduced by diazepam, placebo and CM6912 4 mg, and only slightly by CM6912 2 mg. Task performance was increased by placebo, but wads not affected by diazepam and both doses of CM6912. These results suggest that CM6912 possesses a rather mild anxiolytic effect, and that Fmθmight be a useful tool in precting the clinical efficacy of anxiolytic drugs in normal humans.
本文言語eng
著者キーワードbenzodiazepines
diazepam
CM6912
antianxiety effect
frontal midline theta activity (Fmθ)
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
32
1
開始ページ71
終了ページ77
発行日1985-12
著者版/出版社版出版社版
リポジトリIDA020032000110
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020032000110