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フルテキストURLA020032000109.pdf ( 507.6KB ) 公開日 2010-04-19
タイトルStress-Indused Hypothermia Involves Stimulation of Adenosine A1-Receptors in Rats
作成者Ushijima, Itsuko
Mizuki, Yasushi
Hara, Takahide
Soeda, Koichiro
Kudo, Ryoji
Miyoshi, Akira
Watanabe, Katsumi
Kajimura, Naofumi
Yamada, Michio
作成者ヨミウシジマ, イツコ
ミズキ, ヤスシ
ハラ, タカヒデ
ソエダ, コウイチロウ
クドウ, リョウジ
ミヨシ, アキラ
ワタナベ, カツミ
カジムラ, ナオフミ
ヤマダ, ミチオ
作成者所属山口大学医学部
内容記述(抄録等)Subcutaneous (s.c.) injection of adenosine produced hyperthermia in non-stressed rats and potentiated hypotermia in stressed rats. The potent adenosine A1-recepter stimulants, N6-cyclohexyl adenosine (CHA) and N6-(L-phenylisopropyl) adenosine (L-PIA) prodused hypothermia even in non-stressed rats, which was markedly potentiated in stressed trats. Futhermore, intracerbral ventricular (I.c.v.) injection of adenosine or adenosine analogues produced potentiation of stress-induced hypotermia relative to that induced with s.c.injection. N6-(D-phenylisoprophyl) adenosine (D-PIA) did not affect core temperature. When rats were treated with adenosine 1 h before atress, and then exposed to stress, the hyperthemia exhibited in the non-stressed state changed to hypothermia in the stressed state. When the rats which were treated with adenosine and then atressed for 1 h were released from stress, the hypothermia observed in the atressed state progressively changed to hyperthemia. Low doses of β-endorphin (I.c.v.) and morphine (s.c.)reversed stress-induced hypothermia which was potentiated by CHA, although high doses of β-endorphin (I.c.v.) and morphine (s.c.) potentiated the stress-induced hypothermia. These results suggest that the effects of adenosine on core temperature in rats are altered depending upon the state of animals. Stress-induced hypothermia may be, at least in part, mediated by endogenous adenosine which seems to selectively activate A1-receptor in the stressed state.
本文言語eng
著者キーワードcore temperature
adenosine
adenosine analogs
opiate substances
stressed and nonstressed rats
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
32
1
開始ページ63
終了ページ69
発行日1985-12
著者版/出版社版出版社版
リポジトリIDA020032000109
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020032000109