| フルテキストURL | A020032000109.pdf ( 507.6KB ) 公開日 2010-04-19
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| タイトル | Stress－Indused Hypothermia Involves Stimulation of Adenosine A1－Receptors in Rats |
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| 作成者 | Ushijima, Itsuko
Mizuki, Yasushi
Hara, Takahide
Soeda, Koichiro
Kudo, Ryoji
Miyoshi, Akira
Watanabe, Katsumi
Kajimura, Naofumi
Yamada, Michio
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| 作成者ヨミ | ウシジマ, イツコ
ミズキ, ヤスシ
ハラ, タカヒデ
ソエダ, コウイチロウ
クドウ, リョウジ
ミヨシ, アキラ
ワタナベ, カツミ
カジムラ, ナオフミ
ヤマダ, ミチオ
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| 作成者所属 | 山口大学医学部
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| 内容記述（抄録等） | Subcutaneous (s.c.) injection of adenosine produced hyperthermia in non-stressed rats and potentiated hypotermia in stressed rats. The potent adenosine A1-recepter stimulants, N6-cyclohexyl adenosine (CHA) and N6-(L-phenylisopropyl) adenosine (L-PIA) prodused hypothermia even in non-stressed rats, which was markedly potentiated in stressed trats. Futhermore, intracerbral ventricular (I.c.v.) injection of adenosine or adenosine analogues produced potentiation of stress-induced hypotermia relative to that induced with s.c.injection. N6-(D-phenylisoprophyl) adenosine (D-PIA) did not affect core temperature. When rats were treated with adenosine 1 h before atress, and then exposed to stress, the hyperthemia exhibited in the non-stressed state changed to hypothermia in the stressed state. When the rats which were treated with adenosine and then atressed for 1 h were released from stress, the hypothermia observed in the atressed state progressively changed to hyperthemia. Low doses of β-endorphin (I.c.v.) and morphine (s.c.)reversed stress-induced hypothermia which was potentiated by CHA, although high doses of β-endorphin (I.c.v.) and morphine (s.c.) potentiated the stress-induced hypothermia. These results suggest that the effects of adenosine on core temperature in rats are altered depending upon the state of animals. Stress-induced hypothermia may be, at least in part, mediated by endogenous adenosine which seems to selectively activate A1-receptor in the stressed state.
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| 本文言語 | eng
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| 著者キーワード | core temperature
adenosine
adenosine analogs
opiate substances
stressed and nonstressed rats
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| 主題 | 医学
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University Graduate School of Medicine
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| NII資料タイプ | 紀要論文 |
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| ISSN | 0513-1812
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| NCID | AA00594272
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名別表記 | 山口医科大学紀要 |
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| 巻 | 32 |
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| 号 | 1 |
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| 開始ページ | 63 |
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| 終了ページ | 69 |
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| 発行日 | 1985-12 |
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A020032000109 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020032000109 |
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