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フルテキストURLA020030000105.pdf ( 570.7KB ) 公開日 2010-04-19
タイトルCerebral Circulation and Metabolism during Enflurane Anesthesia in Man
作成者Fujii, Seigo
作成者ヨミフジイ, セイゴ
作成者所属山口大学医学部
内容記述(抄録等)The effects of enflurane anesthesia on cerebral blood flow (CBF) and cerebral metabolic rate for oxgen (CMRo2) were studied in patients. The patients were divided into two groups according to the deph of anesthesia, I.e.,group I, 2% inspried enflurane, and group II, 3.5% inspired enfulurane. Cerebral perfusion pressure (CCP) was maintained above 60 mmHg with phenylephrine. In group I, patients were studied before surgery, while in group II, the measurements were performed before and surgery. In groupe I (enflurane concentration in the arterial blood, 15mg/dl),mean CBF and CMRo2 were 53 and 2.8 ml/100g/min,respectively. These values were not significantly different from CBF (46ml/100g/min) and CMRo2 (3.1 ml/100g/min) in the awake patients. The electroencephalogram (EEG) showed pregominant activities between 12 and 15 Hz with amplitude of 50 to 100чV with nterior dominance. In group II before surgery (enflurance concentration, 27 mg/dl), mean CBF (61 ml/100g/min) and CMRo2 (2.6 ml/100g/min) were significantly diferent from the awake values, while the EEG showed frequent spikes and suppression. In group II during surgery (enflurance concentration 27 mg/dl), mean CBF (67 ml/100g/min) and CMRo2 (2.6 ml/100g/min) were not defferent from the values before surgery despite significant EEG changes (decreased spiking increased suppression) The results indicate that enflurane is a cerebral vasodilator and causes an increse in CBF and a decrese in CMRo2 in man at an anesthetic level characterized by frequent spikes and suppression on the EEG. Nochanges in CBF and CMRo2 despite EEG changes with surgical stimulation suggest redistribution of flow coupled with metabolism.
本文言語eng
著者キーワードAnesthetics
enflurane
Brain
blood flow
oxygen consumption
glicose consumpution
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
30
1
開始ページ39
終了ページ45
発行日1983-12
著者版/出版社版出版社版
リポジトリIDA020030000105
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020030000105