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フルテキストURLA020030000103.pdf ( 1.5MB ) 公開日 2010-04-19
タイトルFuther Examples of Hemoglobin Hirose : Study of Molecular Stability
作成者Ohba, Yuzo
Hattori, Yukio
Takeda, Isamu
Fuyuno, Kikuo
Matsuoka, Miyoko
Yoshinaka, Hiroshi
Satoh, Tomoki
Miyaji, Takaoki
作成者ヨミオオバ, ユウゾウ
ハットリ, ユキオ
タケダ, イサム
フユノ, キクオ
マツオカ, ミヨコ
ヨシナカ, ヒロシ
サトウ, トモキ
ミヤジ, タカオキ
作成者所属山口大学医学部
内容記述(抄録等)Two new cases of Hb Hirose,β37 (CⅢ) Trp→Ser, are reported. Hemoglobin Hirose exhibits propreties, a high oxygen affinity and slightly increased rates of autooxidation, heat denaturation and precipitation on mechanical shaking. These unique properties of Hb Hirose seem to depend on the abnormal manner of association of the aberrant β subunit with the α submit and on the enhanced tendency to dissociate intosubunits. In spite of the abnormal functional properties and the molecular instability of the hemoglobin, none of the carries of Hb Hirose reported so far (only four unrelated Japanese in the world) manifested erythrocytosis or a hemolytic disorder, presumably because the dissociation into subnit is prevent in vivo by the very high hemogrobin concentration in the red blood cell.
本文言語eng
著者キーワードAbnormal hemoglobin
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
30
1
開始ページ21
終了ページ30
発行日1983-12
著者版/出版社版出版社版
リポジトリIDA020030000103
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020030000103