Japanese | English

トップページへ戻る

詳細

   
フルテキストURLA020028000303.pdf ( 578.4KB ) 公開日 2010-04-19
タイトルEffects of Lidocaine and Its N-Dealkylated Metabolite on the Response of Isolated Rabbit Aorta to Transmural Stimulation
作成者Fukuda, Satoru
作成者ヨミフクダ, サトル
作成者所属山口大学医学部
内容記述(抄録等)Effect of zinc ion on the glucose-induced insulin and arginine-induced glucagon release from the isolated perfused rat pancreas was studied. Zinc inhibited insulin release dose-dependently at the concentration of 100 and 200 μM. This inhibition by zinc was observed only in the second phase of glucose-induced insulin release, but not in the first phase. The inhibition by zinc was partial and reversible. Zinc, at 200 μM, also inhibited arginineinduced glucagon release reversibly. Zinc inhibited the activity of phosphodiesterase from rat brain activated in the presence of calcium ion and calmodulin in a dose-dependent manner similarly to trifluoperazine and N-(6-aminohexyl)-5-chloro-1-nephthalenesulfonamide (W-7), specific calmodulin inhibitors. These results suggest that the inhibition of insulin or glucagon release by zinc ion is at least due to the interaction of zinc with the phosphodiesterase activating system, calcium-calmodulin in the pancreatic islets of Langerhans.
本文言語eng
著者キーワードAnesthetics; lidocaine
Lidocaine; sympathetic nerve
metabolites
Smooth muscle; vessels
lidocaine
norepinephrine
sympathetic nerve
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
28
3-4
開始ページ89
終了ページ97
発行日1981-12
著者版/出版社版出版社版
リポジトリIDA020028000303
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020028000303