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フルテキストURLA050059000304.pdf ( 1.2MB ) 公開日 2013-01-30
タイトルMelatonin protects oocyte from reactive oxygen species
作成者Tamura, Hiroshi
Takasaki, Akihisa
Taketani, Toshiaki
Tanabe, Manabu 
Kizuka, Fumie
Lee, Lifa
Tamura, Isao
Maekawa, Ryo
Aasada, Hiromi
Yamagata, Yoshiaki
Sugino, Norihiro
作成者ヨミタムラ, ヒロシ
タカサキ, アキヒサ
タケタニ, トシアキ
タナベ, マナブ
キズカ, フミエ
リ, リファ
タムラ, イサオ
マエカワ, リョウ
アサダ, ヒロミ
ヤマガタ, ヨシアキ
スギノ, ノリヒロ
作成者別表記田村, 博史
高崎, 彰久
竹谷, 俊明
田邊, 学
木塚, 文恵
李, 理華
田村, 功
前川, 亮
浅田, 裕美
山縣, 芳明
杉野, 法広
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)Melatonin (N-acetyl-5-methoxytryptamine) is secreted during the dark hours at night by the pineal gland, and it regulates a variety of important central and peripheral actions related to circadian rhythms and reproduction. Melatonin is believed to regulate ovarian function by the regulation of gonadotropin release in the hypothalamus-pituitary gland axis via its specific receptors. However, it has been discovered that melatonin is a powerful direct free radical scavenger and a broad-spectrum antioxidant. High concentrations of melatonin have been found in human preovulatory follicular fluids. This study focused on the intra-follicular role of melatonin as an antioxidant in the ovary. Reactive oxygen species (ROS), which are locally produced during the ovulatory process, seem to play an essential role on follicle rupture. However, excess ROS can also be responsible for oxidative stress; they can damage oocytes within the follicle. This review shows how melatonin protects oocyte from ROS in the follicle, and contributes to oocyte maturation and embryo development. This review also demonstrated the benefit of melatonin treatment for rtile women to improve oocyte quality.
本文言語eng
著者キーワードmelatonin
oocyte
ovulation
reactive oxygen species
antioxidant
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
59
3-4
開始ページ43
終了ページ51
発行日2012
著者版/出版社版出版社版
リポジトリIDA050059000304
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050059000304