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フルテキストURLA050059000303.pdf ( 1.8MB ) 公開日 2013-01-30
タイトルFocal brain cooling: revisiting a potential therapeutic option for intractable epilepsy
作成者Fujii, Masami
作成者ヨミフジイ, マサミ
作成者別表記藤井, 正美
作成者所属山口大学医学部附属病院
内容記述(抄録等)Seizure control is not achieved in approximately one-third of patients with epilepsy, even with the best available medications. Surgical treatment can be performed for these patients, but this is also not always successful. Under these circumstances, the potential for seizure suppression by focal brain cooling has gained attention. Brain cooling was first proposed about 50 years ago, and has come into the spotlight in recent years with advances in technology. Recent studies indicate that focal cooling of the brain to a cortical surface temperature of 20 to 25℃ terminates epileptic discharges without inducing irreversible neurophysiological dysfunction or neuronal damage. These results have promoted development of implantable focal cooling devices, but some aspects of the hardware in these devices require optimization. However, advances in precision machining have enabled optimization of an implantable focal cooling system, and this suggests that brain cooling therapy may become a reality in the near future.
本文言語eng
著者キーワードepilepsy
focal brain cooling
seizure
device
neuromodulation
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
59
3-4
開始ページ35
終了ページ41
発行日2012
著者版/出版社版出版社版
リポジトリIDA050059000303
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050059000303