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フルテキストURLA050059000302.pdf ( 511.1KB ) 公開日 2013-01-30
タイトルIn vivo real-time monitoring and evaluation for superoxide anion radical generation with an electrochemical sensor
作成者Fujita, Motoki
Maekawa, Tsuyoshi
Todani, Masaki
Tsuruta, Ryosuke
作成者ヨミフジタ, モトキ
マエカワ, ツヨシ
トダニ, マサキ
ツルタ, リョウスケ
作成者別表記藤田, 基
前川, 剛志
戸谷, 昌樹
鶴田, 良介
作成者所属山口大学大学院医学系研究科(医学)
山口大学医学部附属病院
内容記述(抄録等)Recently, we established an in vivo method to directly and continuously monitor and evaluate {O_2}^{-.} using an electrochemical {O_2}^{-.} sensor. The generated {O_2}^{-.} is measured as a current and evaluated as a difference in the current from the baseline to the actual reacted {O_2}^{-.} current (ΔI) and a quantified partial value of electricity (Q), which is calculated by integration of differences between baseline and actual reacted current. To clarify the dynamics of {O_2}^{-.} in vivo and their {O_2}^{-.}-related pathophysiology, the accuracy and efficacy of this method were confirmed in phosphate-buffered saline and human blood and we applied this sensor to rat models of endotoxemia, forebrain ischemia-reperfusion (FBI/R), and heatstroke. This is a novel method for measuring {O_2}^{-.} in vivo, and could be used to monitor and treat the pathophysiology caused by excessive {O_2}^{-.} generation in animals and humans.
本文言語eng
著者キーワードsuperoxide anion radical
electrochemical sensor
endotoxemia
cerebral ischemia-reperfusion
heatstroke
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
59
3-4
開始ページ31
終了ページ34
発行日2012
著者版/出版社版出版社版
リポジトリIDA050059000302
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050059000302