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フルテキストURLA050053000303.pdf ( 727.6KB ) 公開日 2010-04-19
タイトルThe Development of a Novel Method for the Classification of the aCGH Profiles Based on Genomic Alterations
作成者Nakao, Motonao
Okada, Takae
Ikemoto, Kenzo
Furuya, Tomoko
Oga, Atsunori
Kawauchi, Shigeto
Sasaki, Kohsuke
作成者ヨミナカオ, モトナオ
オカダ, タカエ
イケモト, ケンゾウ
フルヤ, トモコ
オガ, アツノリ
カワウチ, シゲト
ササキ, コウスケ
作成者所属山口大学医学部
内容記述(抄録等)Due to recent advances in array technologies, array-based comparative genomic hybridization (aCGH) is now widely used to detect DNA copy number aberrations in cells in the biomedical research field, especially in the field of oncology. However, it may be difficult to make reproducible and consistent categorizations of aCGH profiles. The development of a convenient and reliable classification method for the aCGH profiles is therefore necessary for the clinical application of the aCGH technology. We recently developed a novel classification method for the a CGH profiles besed on genomic alterations in a reproducible fashion. This method has two steps, namely adaptive-weights-smoothing (AWS) and then a self-organizing map (SOM), which thus allows for the automatic classification of the aCGH profiles based on similarities in the genomic aberration pattern. We applied this method to 32 colorectal adenocarcinomas to demonstrate its practical utility. This method may thus be useful for identifying the genomic aberrations implicated in cancer phenotypes and clinicopthological correlations, because this method can be used for all aCGH data.
本文言語eng
著者キーワードarray CGH
colorectal cancer
classification
AWS (Adaptive Weights Smoothing)
SOM (Self Organizing Map)
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
53
3-4
開始ページ37
終了ページ43
発行日2006-12
関連情報URL(IsPartOf)http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
著者版/出版社版出版社版
リポジトリIDA050053000303
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050053000303