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フルテキストURLA020046000302.pdf ( 699.9KB ) 公開日 2010-04-19
タイトルHigh Pressure as a Mechanical Stress and Mitogen-Activated Protein Kinase Activation in Glomerular Diseases
作成者Kawata, Yasunobu
作成者ヨミカワタ, ヤスノブ
作成者所属山口大学医学部
内容記述(抄録等)Progressive renal diseases lead to prolonged glomerular hypertension, which acts as a mechanical stress to mesangial cells and induced the proliferation of mesangial cells. In mesangial cell proliferation, various growth factors and mitogemic stimuli are known to induce the activation of mitogen-activated protein kinase (MAPK), whish serves as an important regulator of transcriptional activity with cell proliferation. Here I review the relationship of glomerular hypertension as a mechanical stress and MAPK activation, which induces glomerular sclerosis through proliferation in mesangial cells.
本文言語eng
著者キーワードmechanical stress
MAP kinase
mesangial cell
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
46
3-4
開始ページ71
終了ページ77
発行日1999-12
著者版/出版社版出版社版
リポジトリIDA020046000302
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020046000302