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フルテキストURLA050055000101.pdf ( 3.2MB ) 公開日 2010-04-19
タイトルHSF1 is important for protection of mouse epidermal cells against heart stress
作成者Nakamura, Chie
Nakamura, Yoshitaka
Gondo, Toshikazu
Takaki, Eiichi
Fujimoto, Mitsuaki
Inouye, Sachiye
Nakai, Akira
Muto, Masahiko
作成者ヨミナカムラ, チエ
ナカムラ, ヨシタカ
ゴンドウ, トシカズ
タカキ, エイイチ
フジモト, ミツアキ
イノウエ, サチエ
ナカイ, アキラ
ムトウ, マサヒコ
作成者別表記中村, 千恵
権藤, 俊一
藤本, 充章
中井, 彰
武藤, 正彦
作成者所属山口大学医学部
内容記述(抄録等)Heat shock transcription factor 1 (HSF1) is essential for transcriptional activation of heat shock genes in response to heat shock in mammals, and is also involved in developmental processes. However, little is known about whether HSF1 regulates expression of heat shock proteins (HSPS) in the epidermis in the presence or absence of heat shock. Here we found that Hspa (Hsp110, Hsp90, Hsp70, Hsp60, Hsp40 and Hsp27) are expressed in unstressed epidermal cells of mouse, mostly by HSF1-independent pathway. To clarify the distribution of Hsp expression in mouse epidermis, we have approached this issue using an in vivo mouse model with chronic cutaneous inflammation and irritation by epicutaneous paintin 5% sodium dodecyl sulfate (SDS). We found that Hsp70 and Hsp27 are highly expressed in the upper epidermal layers, suggesting that their expression is related to keratinocyte differentiation. Hsp70 was highly induced in the mouse epidermis when the skin was exposed to heat shock in vivo. HSF1 is required for its induction, and HSF1-null epidermal cellswere more sensitive to heat shock than wild-type cells. These results indicate that HSF1 is important for protection of mouse epidermal cells against heat stress.
本文言語eng
著者キーワードepidermis
heat shock protein
HSF
mouse
transcription
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
55
1-2
開始ページ1
終了ページ8
発行日2008
関連情報URL(IsPartOf)http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
著者版/出版社版出版社版
リポジトリIDA050055000101
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050055000101