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フルテキストURLA020045000108.pdf ( 1.7MB ) 公開日 2010-04-19
タイトルDetection of K-ras Codon 12 Mutation in the Portal Blood during Surgery for Pancreatic Carcinoma
作成者Enoki, Tadahiko
Morita, Nobuyoshi
Inokuchi, Tomohiro
Tsushimi, Takahiro
Hayashi, Daisuke
Okamura, Keiji
Shinagawa, Hidetaka
Orita, Masahiko
Noshima, Shinji
Esato, Kensuke
作成者ヨミエノキ, タダヒコ
モリタ, ノブヨシ
イノクチ, トモヒロ
ツシミ, タカヒロ
ハヤシ, ダイスケ
オカムラ, ケイジ
シナガワ, ヒデタカ
オリタ, マサヒコ
ノシマ, シンジ
エサト, ケンスケ
作成者所属山口大学医学部
内容記述(抄録等)Background and Aim : It is well known that pancreatic adenocarcinomas harber K-ras gene point mutations, which are frequently restricted to codon 12. Thus, the detection of K-ras codon 12 mutations in pancreatic or duodenal juice may did in the diagnosis of pancreatic adenocarcinomas. In the present study, we investigated whether or not portal blood collected during surgery for pancreatic adenocarcinoma contains the K-ras codon 12 mutation. Methods : During radical resection for pancreatic adenocarcinoma, 10ml of portal blood was taken twice ; first immediately after laparotomy, then just before resection. K-ras mutation was analyzed by a polymerase chain reaction using the primars corresponding to mutant alleles. Results : K-ras mutation was identefied in three of nine patients with pancreatic adenocarclinoma immediately before resection, while none of the patients were positive at the time of laparotomy. The K-ras status in the portal bllod did not correlate with microscopic venous or lymphataic invation. Conclusion : K-ras mutations were identified in portal bllod in some patients with pancreatis adenocarcinoma, which indicates that pancreatic cancer cells migrated into portal bllod during resection and that some adjuvant therapy during surgery may be necessary to cure the pancreatic cancer.
本文言語eng
著者キーワードK-ras codon 12 mutation
liver metastasis
pancreas carcinoma
portal blood
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
45
1-4
開始ページ51
終了ページ56
発行日1998-12
著者版/出版社版出版社版
リポジトリIDA020045000108
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020045000108