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フルテキストURLA020022000208.pdf ( 1.1MB ) 公開日 2010-04-16
タイトルSerum Hepatitis B Antigen Particles in various Liver Diseases : Relation to Immunological Tests for Hepatitis B Antigen
作成者Harada, Toshinori
Takenami, Toshihiko
Kodama, Takahiro
Fujita, Teruo
作成者ヨミハラダ, トシノリ
タケナミ, トシヒコ
コダマ, タカヒロ
フジタ, テルオ
作成者所属山口大学医学部
内容記述(抄録等)Immunological detection of HBAg and the electron-microscopic observation of HBAg particles were performed on 196 serum samples collected from a total of 183 cases consisting of 58 of acute hepatitis, 8 of prolonged hepatitis, 60 of chronic hepatitis, 30 of liver cirrhosis, 21 of hepatoma and 6 of fulminant hepatitis, and the results obtained by both techniques were studied comparatively. As the result, the discrepancy between both techniques was noted in 19.9% (35/196) of the total serum samples, and almost all of the discrepancy was seen in the serum samples which were negative for HBAg by radioimmunoassay but exhibitid the particles electron-microscopically. The incidence of HBAg in various liver diseases determined electron-microscopically was recorded at 63.7% (37/58) for acute hepatitis, at 60% (36/60) for chronic hepatitis including 66.6% (26/39) for aggresive form, at 50% (15/30) for liver cirrhosis and at 71.4% (15/21) for hepatoma, and these values were more than 10% higher than those determined by immunological techniques. These results indicated that electron microscopy was a more sensitive method than immunological tests for detecting HBAg and supported the hypothesis that HBAg may play some role in the development of chronic liver disease and hepatoma.
本文言語eng
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
22
2
開始ページ265
終了ページ273
発行日1975-06
著者版/出版社版出版社版
リポジトリIDA020022000208
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020022000208