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フルテキストURLA050058000303.pdf ( 548.7KB ) 公開日 2012-03-16
タイトルGenotyping of human killer cell immunoglobulin-like receptor genes in Japanese patients with psoriatic arthritis, generalized pustular psoriasis or psoriasis vulgaris
作成者Nemoto, Kei
Muto, Masahiko
作成者ヨミネモト, ケイ
ムトウ, マサヒコ
作成者別表記根本, 圭
武藤, 正彦
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)The interaction of HLA-C with killer immunoglobulin-like receptors (KIRs) on natural killer cells and some natural killer-T cells together with a strong association between HLA (human leukocyte antigen), especially HLA-Cw*06, and psoriasis indicates that this is an immune-mediated disorder. The association between KIRs and psoriatic arthritis (PA) and generalized pustular psoriasis (GPP) was investigated by typing 14 KIR genes from Japanese patients with GPP, PA or psoriasis vulgaris (PV) using PCR. Frequencies of KIR2DS1 and KIR2DL5, which was in linkage disequilibrium with KIR2DS1, were significantly increased in PV cases when compared with controls. We report an increase in KIR2DS1 and KIR2DL5 in Japanese patients with GPP and PV. The KIR haplotype (KIR2DS1+2DS2+2DS3) in PA cases occurred more frequently than in GPP and PV cases. Thus, KIR2DS1 may be a common factor in susceptibility to psoriasis, although the variation in the frequencies of HLA-C and KIRs in cases of PV, GPP, and PA indicates that other genetic factors are also involved.
本文言語eng
著者キーワードsusceptibility to psoriasis
human leukocyte antigen
natural killer cells
killer cell immunoglobulin-like receptors
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
58
3-4
開始ページ37
終了ページ43
発行日2011
著者版/出版社版出版社版
リポジトリIDA050058000303
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050058000303