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フルテキストURLA050058000302.pdf ( 1.2MB ) 公開日 2012-03-16
タイトルTopical application of substance P facilitates vestibular functional recovery induced by AMPA in the guinea pig
作成者Toyota, Hideki
Shimogori, Hiroaki
Sugahara, Kazuma
Yamashita, Hiroshi
作成者ヨミトヨタ, ヒデキ
シモゴオリ, ヒロアキ
スガハラ, カズマ
ヤマシタ, ヒロシ
作成者別表記豊田, 英樹
下郡, 博明
菅原, 一真
山下, 裕司
作成者所属山口大学大学院医学系研究科(医学)
山口大学医学部附属病院
内容記述(抄録等)Hypothesis: Topical Substance P (SP) application facilitates recovery from vestibular disorders induced by (±)-α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) in guinea pigs and may offer a treatment strategy for patients with peripheral vestibular disorders. Methods: Sixteen Hartley white guinea pigs were assigned to groups administered with SP and artificial perilymph. A hole was drilled adjacent to a round window and AMPA was infused into the hole to induce a vestibular disorder. Thereafter, SP or artificial perilymph was delivered via an osmotic pump inserted into the hole. We observed spontaneous nystagmus and measured vestibulo-ocular reflexes (VOR) gains using sinusoidal rotation tests. Results: Spontaneous nystagmus decreased immediately after SP infusion, and the gain ratios were significantly higher than those in the control group at 3 and 7 days after treatment. Conclusion: Topical SP application facilitates recovery from AMPA-induced vestibular disorders in guinea pigs.
本文言語eng
著者キーワードvestibular disease
substance P
vestibulo-ocular reflex
AMPA
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
58
3-4
開始ページ31
終了ページ36
発行日2011
著者版/出版社版出版社版
リポジトリIDA050058000302
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050058000302