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フルテキストURLA020037000302.pdf ( 4.5MB ) 公開日 2010-04-19
タイトルNerves Versus Hormones in the Regulation of an Organism
作成者Fujita, Tsuneo
作成者ヨミフジタ, ツネオ
作成者所属山口大学医学部
内容記述(抄録等)The pendulum of conceots cincerning the regulatory mechanism of the gut dramatically swung from the nervism of Pavlov the hormonism of Bayliss and Starling, and recently to a compromise on the prerequisite of sensory nerves recognizing food chemical information and transmitting it to endocrine cells. Our studies have settled this problem by neglecting this intervention of nerves and demonstrating the endocrine cells as being open to the lumen to recognize luminal stimuli. The cells thus are half nervous and half secretory in nature; this recognition has motivated us to propose a cell family of paraneurons. Advances in studies have indicated that neurons and paraneurons comprise a continuous and unseparable entity, their roles regulating the organs being also unseparable. The signal substances (peptides and in some cells also amines) are common tonesrons and paraneurons; the routes and distances they travel to their targets show every gradation without regard to their source cell, whether neuron or paraneuron. These data indicate that transmitters and hoemones are overlapping and unseparable. Phylogenetical studies have clarified that the peptide producing regulatory cells are derived from the intraepithelial bipolar paraneurons and subepithelial multipolar neurons occurring in Hydra (Coelenterata). These prototype cells are inherited, without ant large modification, in our gut wall, to sontinue their ancient task, i.e., to recognize food information, to respond to it adequately for effective nutrition uptake, and to protect the body against toxic invasions.
本文言語eng
著者キーワードNerves
Hormones
Paraneurons
Gut endocrine cells
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
37
3-4
開始ページ65
終了ページ77
発行日1990-12
著者版/出版社版出版社版
リポジトリIDA020037000302
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020037000302