Japanese | English

トップページへ戻る

詳細

   
フルテキストURLA050058000102.pdf ( 1.1MB ) 公開日 2011-12-19
タイトルBone marrow stem cells contribute to cardioprotection in the late phase of ischemic preconditioning
作成者Kamota, Takahiro
Li, Tao-Sheng
Morikage, Noriyasu
Murakami, Masanori
Ohshima, Mako
Kubo, Masayuki
Kobayashi, Toshiro
Mikamo , Akihito
Hamano, Kimikazu
作成者ヨミカモタ, タカヒロ
リ, タオセン
モリカゲ, ノリヤス
ムラカミ, マサノリ
オオシマ, マコ
クボ, マサユキ
コバヤシ, トシロウ
ミカモ, アキヒト
ハマノ, キミカズ
作成者別表記鴨田, 隆弘
李, 桃生
森景, 則保
村上, 雅憲
大島, 真子
久保, 正幸
小林, 俊郎
美甘, 章仁
濱野, 公一
作成者所属山口大学医学部附属病院
内容記述(抄録等)Ischemic preconditioning (IPC) is a well-known innate phenomenon, in which brief exposure to sublethal ischemia protects organs from subsequent ischemia/reperfusion (I/R) injury. The protective effects after IPC occur in two distinct phases: an early phase and a late phase. However, the exact protective mechanism of IPC is not fully understood, especially in the late phase. Based on increasing evidence that bone marrow stem cells (BMSCs) can repair the injured heart, we investigated whether they also play a role in protecting the heart against I/R injury in the late phase of IPC. We observed an increase in cardioprotective factors in the serum in the early phase, but an increase in BMSCs in the circulating blood in the late phase after remote IPC. Using a heart I/R injury model, we demonstrated that the mobilized BMSCs were recruited into the injured heart and contributed to cardioprotection, especially in the late phase of IPC. Our results indicate that IPC enhances the mobilization and recruitment of BMSCs in the late phase to protect the heart against I/R injury.
本文言語eng
著者キーワードischemic preconditioning
late phase
bone marrow stem cells
mobilization
recruitment
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
58
1-2
開始ページ7
終了ページ10
発行日2011
著者版/出版社版出版社版
リポジトリIDA050058000102
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050058000102