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フルテキストURLA050057000302.pdf ( 660.2KB ) 公開日 2011-03-29
タイトルArteriosclerosis and vascular endothelial function in chronic liver disease
作成者Suenaga, Hiromi
Sakaida, Isao
Korenaga, Keiko
Okamoto, Takeshi
Segawa, Makoto
Uchida, Kouichi
Hinoda, Yuji
作成者ヨミスエナガ, ヒロミ
サカイダ, イサオ
オカモト, タケシ
セガワ, マコト
ウチダ, コウイチ
ヒノダ, ユウジ
作成者別表記末永, 弘美
坂井田, 功
岡本, 健志
瀬川, 誠
内田, 耕一
日野田, 裕治
作成者所属山口大学大学院医学系研究科(医学)
山口大学医学部附属病院
内容記述(抄録等)Background: Patients with chronic liver disease (CLD) are known to have a low incidence of cardiovascular events. However, the extent of arteriosclerosis in CLD has not been studied well. Aims: To assess arteriosclerosis in CLD, and to assess and examine vascular endothelial function. Methods: The subjects were 17 patients with chronic hepatitis (CH), 48 patients with liver cirrhosis (LC), and 18 non-CLD patients (control) with no history of cardiovascular events (coronary artery disease: CAD). Arteriosclerosis was assessed by ultrasonic determination of intima-media complex thickness (IMT) and stiffness parameter (β value) of the common carotid artery. Vascular endothelial function was assessed by determining flow-mediated dilatation (FMD) of the brachial artery. Nitrogen oxides (NOx), angiotensin II (AG II), and endothelin-1 (ET-1) were measured as vasoactive substances in the serum of all subjects. The concentration of adiponectin, which has antiatherogenic action, was also measured in the serum of all subjects. Results: No significant differences in IMT or β value were found between the groups. The FMD in CH (5.8 ± 1.9%) was significantly higher compared to the control (3.4 ± 1.4%) (F=3.3, p=0.015). The serum concentrations of ET-1 and adiponectin in CLD patients were greater the more advanced the disease. Conclusions: There were no apparent differences in the extent of arteriosclerosis between CLD and the control, while vascular endothelial function in CLD was better preserved compared to the control, which may be attributable to the antioxidant action of nitric oxide (NO) and/or the antiatherogenic action of adiponectin.
本文言語eng
著者キーワードarteriosclerosis
vascular endothelial function
chronic liver disease
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
57
3-4
開始ページ33
終了ページ40
発行日2010
関連情報URL(IsPartOf)http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
著者版/出版社版出版社版
リポジトリIDA050057000302
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050057000302