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フルテキストURLA050057000303.pdf ( 871.0KB ) 公開日 2011-03-29
タイトルAnalysis of single nucleotide polymorphisms of methylenetetrahydrofolate reductase in Japanese psoriasis patients
作成者Deguchi, Hirotaka
Tanaka, Akemi
Muto, Masahiko
作成者ヨミデグチ, ヒロタカ
タナカ, アケミ
ムトウ, マサヒコ
作成者別表記出口, 弘隆
田中, 朱美
武藤, 正彦
作成者所属山口大学大学院医学系研究科(医学)
内容記述(抄録等)Methotrexate (MTX) is an effective drug for the treatment of psoriasis as well as rheumatoid arthritis. We investigated the correlation between single nucleotide polymorphisms (SNP) in methylenetetrahydrofolate reductase (MTHFR) and susceptibility to psoriasis in 175 psoriasis patients and 150 healthy controls and between MTHFR SNP and responsiveness to psoriasis treatment in 7 psoriasis patients. The frequencies of the 677C allele in the patient and healthy control groups were 0.61 and 0.57, respectively, while those of the 677T allele were 0.39 and 0.43, respectively. Both allele frequencies in both groups were not significantly different. Moreover, both groups showed the same frequency of 1298A allele (0.83 vs. 0.83) and 1298C allele (0.17 vs. 0.17). The frequency of MTHFR SNP and susceptibility to psoriasis were not correlated. Additionally, MTHFR SNP frequency and the psoriasis lesion were not correlated. Investigation of the MTX treatment efficacy in 7 patients revealed that the drug was effective in psoriasis patients with positive presumed 677C–1298A SNP haplotypes (N = 3), and they developed no side effects. Although MTHFR SNP involved in folate metabolism is not related to susceptibility to psoriasis and its severity, SNP could become a predictive index to use MTX safely and effectively in psoriasis treatment.
本文言語eng
著者キーワードfolic acid
methotrexate
methylenetetrahydrofolate reductase
polymorphism
disease susceptibility to psoriasis
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
57
3-4
開始ページ41
終了ページ48
発行日2010
関連情報URL(IsPartOf)http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
著者版/出版社版出版社版
リポジトリIDA050057000303
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050057000303