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フルテキストURLA020037000305.pdf ( 528.2KB ) 公開日 2010-04-19
タイトルQuantitative Evaluation of the Inactivation of Human Immunodeficiency Virus (HIV) by Antiseptics for the Oral Cavity
作成者Suzuki, Michihiko
Nakashima, Hideki
Shinozaki, Fumihiko
作成者ヨミスズキ, ミチヒコ
ナカシマ, ヒデキ
シノザキ, フミヒコ
作成者所属山口大学医学部
内容記述(抄録等)Antiseptics used for the oral cavity were tested for the inactivation of human immunodeficiency virus (HIV). A quantitative bioassay system with a HTLV-Ⅰ - carrying human T-cell line, MT-4 was used to evaluate virus inactivation. The tested compounds were as follows: povidone-iodine; benzethonium chloride; benzalconium chloride; chlorhexidine digluconate; methylrosaniline chloride; benzalconium chloride; chlorhexidine digluconate; methylrosaniline chloride; and ethacridine lactate. These compounds were tested at final concentrations of 1.0%, 0.1%, 0.01% and 0.001%, in the presence or absence of 10% fetal calf serum. The immunofluorescence assay for the HIV antigen showed that povidone-iodine, benzethonium chloride, and chlorhexidine digluconate were effective in the inactivation of HIV at concentrations for oral use. However, in the presence of protein, benzethonium chloride and chlorhexidine digluconate were ineffective at the indicated concentrations for oral use. Although benzalconium chloride was effective at 0.1%, this concentration cannot be used orally. Ethacridine lacate and methylrosaniline chloride were not effective at non-cytotoxic concentrations. The inhibitory effect of povidone-iodine was further tested by a HIV-specific plaque forming assay. The virus treated with concentrations higher than 0.1% of providone-iodine inactivator of HIV for use as an oral actiseptic in routine dental practice.
本文言語eng
著者キーワードInactivation
HIV
Oral antiseptics
Povidone-iodine
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
37
3-4
開始ページ95
終了ページ100
発行日1990-12
著者版/出版社版出版社版
リポジトリIDA020037000305
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020037000305