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フルテキストURLA020044000304.pdf ( 810.8KB ) 公開日 2010-04-19
タイトルCorrelation Between Behavioral Alteration to Chronic Cocaine Treatment and G-Protein ADP-Ribosylation in Mice.
作成者Ushijima, Itsuko
Kobayashi, Takayoshi
Akimoto, Takashi
Jing, Sheng Zi
Mitsuno, Shigeru
Watanabe, Katsumi
Yamada, Michio
作成者ヨミウシジマ, イツコ
コバヤシ, タカヨシ
アキモト, タカシ
ミツノ, シゲル
ワタナベ, カツミ
ヤマダ, ミチオ
作成者所属山口大学医学部
内容記述(抄録等)The role of Gi-proteins on cataleptic responses induced by SCH23390, a dopamine D1 receptor antagonist, and haloperidol, a mainly dopamine D2 receptor antagonist, one day after chronic cocaine treatment in mice was examined by injecting intravenously (i.v.) pertussis toxin, which catalyzes adenosine diphosphate (ADP)-ribosylation of Gi-proteins. SCH23390- and haloperidol-induced catalepsy was potentiated 3-24 h after administration of a single dose (5 and 10mg/kgi.v.) of the toxin, but not at 1 mg/kg. It was apparent that the longer the time interval between pertussis toxin and dopamine antagonists treatments, snd the higher the dose of pertussis toxin, the greater were the cataleptic reponses. Mice given subcutaneous administration (s.c.) of cocaine (10mg/kg) once every other day for 15 days (a total of 8 injections) exhibited an attenuated SCH23390-induced catalepsy (SCH23390 catalepsy) and an enhanced haloperidol-induced catalepsy (haloperidol catalepsy9 one day after the last cocaine injection.The inhibitory effect of chronic cocaine treatment on SCH23390 catalepsy was enhancing effect of that on haloperidol catalepsy was fuether enhanced with same dose of toxin. These results suggest that there may be an interrelationship between Gi-protein ADP-ribosylation and D2 receptor subsensivity (enhanced haloperidol catalepsy) induced by chronic cocaine treatment, whereas an opposite relationship exists between D1 peceptor supersensitivity (attenuation of SCH23390 catalepsy) induced by chronic cocain treatment and the ribosylation. Accordingly, behavioral sensitization (reverse tolerance) seen one day after chronic cocaine treatment, which result in D1 ewcwptor supersensitivity and D2 receptor subsensitivity may not involve Gi protein ADP-rebosylation.
本文言語eng
著者キーワードCocaine
SCH23390
Haloperidol
Pertussis toxin
Catalepsy
Gi-protein
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
44
3-4
開始ページ71
終了ページ78
発行日1997-12
著者版/出版社版出版社版
リポジトリIDA020044000304
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020044000304