| フルテキストURL | A020044000304.pdf ( 810.8KB ) 公開日 2010-04-19
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| タイトル | Correlation Between Behavioral Alteration to Chronic Cocaine Treatment and G-Protein ADP-Ribosylation in Mice. |
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| 作成者 | Ushijima, Itsuko
Kobayashi, Takayoshi
Akimoto, Takashi
Jing, Sheng Zi
Mitsuno, Shigeru
Watanabe, Katsumi
Yamada, Michio
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| 作成者ヨミ | ウシジマ, イツコ
コバヤシ, タカヨシ
アキモト, タカシ
ミツノ, シゲル
ワタナベ, カツミ
ヤマダ, ミチオ
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| 作成者所属 | 山口大学医学部
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| 内容記述（抄録等） | The role of Gi-proteins on cataleptic responses induced by SCH23390, a dopamine D1 receptor antagonist, and haloperidol, a mainly dopamine D2 receptor antagonist, one day after chronic cocaine treatment in mice was examined by injecting intravenously (i.v.) pertussis toxin, which catalyzes adenosine diphosphate (ADP)-ribosylation of Gi-proteins. SCH23390- and haloperidol-induced catalepsy was potentiated 3-24 h after administration of a single dose (5 and 10mg/kgi.v.) of the toxin, but not at 1 mg/kg. It was apparent that the longer the time interval between pertussis toxin and dopamine antagonists treatments, snd the higher the dose of pertussis toxin, the greater were the cataleptic reponses. Mice given subcutaneous administration (s.c.) of cocaine (10mg/kg) once every other day for 15 days (a total of 8 injections) exhibited an attenuated SCH23390-induced catalepsy (SCH23390 catalepsy) and an enhanced haloperidol-induced catalepsy (haloperidol catalepsy9 one day after the last cocaine injection.The inhibitory effect of chronic cocaine treatment on SCH23390 catalepsy was enhancing effect of that on haloperidol catalepsy was fuether enhanced with same dose of toxin. These results suggest that there may be an interrelationship between Gi-protein ADP-ribosylation and D2 receptor subsensivity (enhanced haloperidol catalepsy) induced by chronic cocaine treatment, whereas an opposite relationship exists between D1 peceptor supersensitivity (attenuation of SCH23390 catalepsy) induced by chronic cocain treatment and the ribosylation. Accordingly, behavioral sensitization (reverse tolerance) seen one day after chronic cocaine treatment, which result in D1 ewcwptor supersensitivity and D2 receptor subsensitivity may not involve Gi protein ADP-rebosylation.
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| 本文言語 | eng
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| 著者キーワード | Cocaine
SCH23390
Haloperidol
Pertussis toxin
Catalepsy
Gi-protein
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| 主題 | 医学
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University Graduate School of Medicine
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| NII資料タイプ | 紀要論文 |
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| ISSN | 0513-1812
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| NCID | AA00594272
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名別表記 | 山口医科大学紀要 |
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| 巻 | 44 |
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| 号 | 3-4 |
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| 開始ページ | 71 |
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| 終了ページ | 78 |
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| 発行日 | 1997-12 |
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A020044000304 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020044000304 |
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