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フルテキストURLA020042000309.pdf ( 544.9KB ) 公開日 2010-04-19
タイトルEffect of Enteral Nutrition on Intestinal Permeability in Critically III Patients -Preliminary Report-
作成者Ueno, Tomio
Oka, Masaaki
Suzuki, Takashi
Soejima, Yoshiyuki
Murakami, Fujio
Ueda, Toshiko
Tateishi, Akiko
Maekawa, Tsuyoshi
作成者ヨミウエノ, トミオ
オカ, マサアキ
スズキ, タカシ
ソエジマ, ヨシユキ
ムラカミ, フジオ
ウエダ, トシコ
タケイシ, アキコ
マエカワ, ツヨシ
作成者所属山口大学医学部
内容記述(抄録等)It has been reported that intravenous injection of endotoxin increases intestinal permeability in human, and that total parenteral nutrition promotes bacterial translocation from the gut. In the present study, the effect of enteral nutrition on intestinal permeability and its relationship to plasma endotoxin levels were evaluated. Intestinal permeability was assessed in six stressed patients who were intubated for acute respiratory failure. The examination was performed before and after 7 days of feeding using the dual-sugar intestinal permeability test, with lactulose and mannitol as markers. Plasma endotoxin levels were also measured by the endotoxin-specific colorimetric limulus test before and after an enteral diet. The mean±SD lactulose to mannitol excretion ratio (L/M ratio), a permeability index, before enteral nutrition was 0.108±0.111, which was extremely high compaired to reported value of healthy volunteers. This value was declined to 0.042±0.067 after enteral nutrition, although p value (0.068) was not reached statistical significance. The mean plasma endotoxin level, which may have been related to concomitant respiratory infection, was 10.08±2.80 pg/ml before, and 18.48±12.39 pg/ml after enteral feeding (p=0.075). Despite the elevation of endotoxin, there was a tendency to meke intestinal permeability improve after enteral feeding. This suggests that the increased progression of intestinal permeability due to endotoxemia, fasting, and acute stress might be prevented by enteral feeding.
本文言語eng
著者キーワードEnteral nutrition
Intestinal permeability
Endotoxin
Endotoxemia
Lactulose-mannitol differential sugar absorption
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
42
3-4
開始ページ99
終了ページ103
発行日1995-12
著者版/出版社版出版社版
リポジトリIDA020042000309
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020042000309