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フルテキストURLA050055000303.pdf ( 620.1KB ) 公開日 2010-04-19
タイトルAssociations between markers of inflammation and cholinergic blockade and delirium in intensive care unit patients: A pilot study
作成者Tsuruta, Ryosuke
Girard, Timothy D
Ely, E. Wesley
Fujimoto, Kenji
Ono, Takeru
Tanaka, Ryo
Oda, Yasutaka
Kasaoka, Shunji
Maekawa, Tsuyoshi
作成者ヨミツルタ, リョウスケ
フジモト, ケンジ
オノ, タケル
タナカ, リョウ
オダ, ヤスタカ
カサオカ, シュンジ
マエカワ, ツヨシ
作成者別表記鶴田, 良介
小野, 建
小田, 泰崇
笠岡, 俊志
前川, 剛志
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)The purpose of this study was to determine the associations of serum C-reactive protein (CRP) and plasma anticholinergic activity (PAA) with delirium in critically ill and injured patients. Prospective cohort study of 32 patients admitted a university-based intensive care unit. All patients were evaluated for delirium with the Confusion Assessment Method for the Intensive Care Unit, and blood was collected for measurement of serum CRP and PAA. These biomarkers and other factors, including patient demographics, intubation, and Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ and Sequential Organ Failure Assessment (SOFA) scores were compared between patients who developed delirium and those who did not. Furthermore, the levels of serum CRP and PAA were examined for correlation with each other. Intubated and mechanically ventilated patients were more likely to be delirious than non-intubated patients (p < 0.001). The APACHE Ⅱ and SOFA scores were significantly higher in delirious patients than in non-delirious patients (p = 0.007 and p = 0.04, respectively). Serum CRP levels were significantly higher in intubated patients (p < 0.02) as were PAA levels (p = 0.001). A moderately strong correlation was found between serum CRP and PAA in the enrolled patients (Spearman's rho = 0.65, p<0.0001). Inflammation and cholinergic blockade, as measured by serum CRP and PAA levels, respectively, were associated with delirium in this study of critically ill patients, and serum CRP and PAA were correlated with each other.
本文言語eng
著者キーワードdelirium
inflammation
C-reactive protein (CRP)
acetylcholine
Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
55
3-4
開始ページ34
終了ページ42
発行日2008
関連情報URL(IsPartOf)http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
著者版/出版社版出版社版
リポジトリIDA050055000303
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050055000303